Gardner’s syndrome

DIRECTLY HEREDITARY. Some known hereditary cancers of man include retinoblastoma multiple polyps of the colon Gardner s syndrome chemodectoma pheodiromocy-toma and thyroid cancer. Fortunately, all these are relatively rare and contribute little to the total cancer causes. However, study of these cancers may help determine the actual importance of genetic susceptibility to cancer. 

Adenomatous polyps are most often located around the papilla of Vater. They may be single or multiple, usually small and never obstructing (Fig. 3.51). The relationship to polyposis syndromes, above all FAP and Gardner s syndromes, is well established. In these patients multiple polyps are found in the second and third parts of the duodenum, and as adenomatous lesions are precursors to periampullary carcinoma, they should be followed up if not removed. 

Williams SC, Peller PJ (1994) Gardner s syndrome. Case report and discussion of the manifestations of the disorder. Clin Nuc Med 19 668-670 Wise SW (2000) Case 24 afferent loop syndrome. Radiology 216 142-145... 

Fig. 7.39. Upper gastrointestinal series with water-soluble contrast material obtained 5 years after multivisceral transplantation in 41-year-old woman with Gardner s syndrome and intra-abdominal desmoid tumor, (d donor, r recipient, ST stomach.) Annotations intestinal graft (asterisk), urethral drainage tube (arrowhead). Image shows normal postoperative anatomy after end-to-end gastrogastrostomy with normal intestinal contrast passage (exact position of end-to-end gastrogastrostomy not discernihle)...

In the following year, Kuzell, Schaffarzick, Mankle and Gardner [242] published their study of copper therapy in a variety of rheumatoid and degenerative diseases. The purpose of their clinical study was to evaluate cuproxoline and allocupreide in patients who had RA, RA with psoriasis, Reiter s syndrome, ankylosing spondylitis, and chronic gouty arthritis, as shown in Table 6.11. 

Gardner, J. M., Nakatsu, Y., Gondo, Y., Lee, S., Lyon, M. F., King, R. A., and Brilliant, M. H. (1992). The mouse pink-eyed dilution gene association with human Prader-Willi and Angelman syndromes. Science 257 1121-1124. 

MacRae AR, Gardner HA, Allen LC, Tokmakejian S, Lepage N. Outcome validation of the Beckman Coulter access analyzer in a second-trimester Down syndrome serum screening application. Clin Chem... 

Rizzo W.B., Craft D.A., Kelson T.L., Bonnefont J.P., Saudubray J.M., Schulman J.D., Black S.H., Tabsh K., Dirocco M., Gardner R.J., Prenatal diagnosis of Sjogren-Larsson syndrome using enzymatic methods. Prenatal diagnosis 14 (1994) 577-581. 

Lim S, Prasad MR, Samuels P, Gardner DK, Cordero L. High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome. Am J Obstet Gynecol 2009 200(1) 70.el-5. 

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