Ganglioside GQlb

Immune attack on antigen accessible in PNS, not CNS (e.g. gangliosides GQlb and GTla)... 

Seishima, M., Aoyama, Y., Mori, S., and Nozawa, Y., Involvement of phosphohpase D in ganglioside GQlb-induced biphasic diacylglycerol production in human keratinocytes, J. Invest. Dermatol., 104, 835, 1995. 

Chiba A, Kusimoki S, Shimizu T, Kanazawa I (1992) Serum IgG andbody to ganglioside GQlb is a possible marker of Miller Fisher syndrome. Ann Neurol 31 677—679. 

Fisher syndrome has been associated with previous C. jejuni infection. In Miller Fisher syndrome, antibodies to the ganglioside GQlb have been shown to produce neuromuscular block and may in part explain the clinical signs of that disorder (Willison Yuki, 2002). 

Figure 2. Structure of ganglioside GQlb, one of the major gangliosides occurring in human brain. I-IV indicate the neutral sugar residues relevant for nomenclature I, glucose II, inner galactose III, A -acetylgalactosamine IV, outer galactose. Ac, acetyl.

Ganglioside GQIb Scheme 11.7 Total synthesis of ganglioside GQlb. 

An efficient method for obtaining disialyl glycoside is the use of dimeric sialic acid donor, which can be readily prepared from naturally available colominic acid. As shown in Scheme 5 [21], ganglioside GQlb can be synthesized in almost same procedure as that of GDI a by employing dimeric sialic acid in place of monomeric sialic acid, except for the construction of GD2 which is the key intermediate for the synthesis of GQlb. 

Tsuji, S., Yamashita, T., and Nagai, Y, 1988, A novel, carbohydrate signal-mediated cell surface protein phosphorylation Ganglioside GQlb stimulates ecto-protein kinase activity on the cell surface of a human neuroblastoma cell line, GOTO, J. Biochem. 104 498-503. 

Figure 7. Specific binding of Sendai virus to GQlb ganglioside and its inhibition by antiserum as demonstrated with (a) the VCS method and (b) hemadsorption (see text). A virus in fourfold serial dilutions in buffer B in lower-titer antiserum, 1% C in the same serum, 10% D in higher titer antiserum, 1% this serum, 10%.

Tsuji, S., Arita, M., and Nagai, Y. (1983). GQlb, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in two neuroblastoma cell lines. J. Biochem. 94, 303-306. 

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