GalNAc-specific

T. K. Dam, T. A. Gerken, B. S. Cavada, K. S. Nascimento, T. R. Moura, and C. F. Brewer, Binding studies of a-GalNAc specific lectins to the a-GalNAc (Tn-antigen) form of porcine submaxillary mucin and its smaller fragments, J. Biol. Chem., 282 (2007) 28256-28263. 

S. Sakai, Y. Shigemasa, and T. Sasaki, A self-adjusting carbohydrate ligand for GalNac specific lectins, Tetrahedron Lett., 38 (1997) 8145-8148. 

Sakai, S. Shigemasa, Y Sasaki, T. lron(ll)-assisted assembly of trivalent GalNAc clusters and their interactions with GalNAc-specific lectins. Bull. Chem. Soc. Jpn. 1999, 72, 1313-1319. 

Preparation of cluster glycosides of A-acetylgalactosamine that have subnanomolar binding constants towards the mammalian hepatic Gal/GalNAc-specific receptor. [R. T. Lee, Y. C. Lee, Glycoconjugate J. 1987, 4, 317-328] [ 38]. 

Khan, M.J., Joginadha Swamy, M., Krishna Sastry, M.V., Umadevi Sajjan, S., Patanjali, S.R., Rao, P., Swarnalatha, G.V., Banerjee, P. and Surolia, A. (1988). Saccharide binding to three Gal/GalNac specific lectins Fluorescence, spectroscopic and stopped-flow kinetic studies. Glycoconjugate Journal, 5, 75-84. 

This group of lectins, among the earliest to be investigated among plant agglutinins, vary in their specificity from those which are primarily GalNAc-specific, to those which exhibit little specificity toward either sugar, to those which are most specific for Gal. 

Scheme 5.10 Dynamic generation around a metal-coordination center targeting GalNAc-specific plant lectins.

Kurosawa N, Kojima N, Inoue T, Hamamoto T, Tsuji S. Cloning and expression of Gal pi, 3 GalNAc- specific GalNAca2,6-sialyltransferase. J. Biol. Chem. 1994 269 19048-19053. 

Joe, A, IDH Hamer, MA Kelley, MEA Pereira, GT Keusch, S Tzipori, and HD Ward (1994) Role of a Gal/GalNAc-specific sporozoite surface lectin in Cryptosporidium parvum-host cell interaction. J Eukaryot Microbiol 41 44S. 

Fig. 2 Chemical synthesis and on-slide enrichment of glycopeptides. (a) Solid-phase glycopeptide synthesis with A/-acetylation capping step, (b) MALDI-TOF spectra of crude Tn-MUC1 20mer glycopeptide. (c) On-slide microarray enrichment of crude Tn-MUC1 20mer glycopeptide product via amine-reactive glass surface and detection of GalNAc-specific lectin (WL)...

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