Galectins structure

Fig. 6 Structure of human galectin-3 CRD in complex with a lactose moiety bearing a lanthanide binding tag. Significant chemical shift perturbations (PCS) in the protein (residues represented as sticks) can be detected upon ligand binding (modelled from galectin structure PDB 2NN8).

Figure 13.2 The crystal structures of (a) concanavalin A and (b) the carbohydrate recognition domain of galectin-3. Residues in the carbohydrate binding sites are black.

Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM. X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1 A resolution. J Biol Chem 1998 273 13047-13052. 

X-ray crystal structures of the lectin domains of human and bovine galectin 1, galectin 10 and similar domains from other proteins. (Reproduced with permission from [181])... 

X-ray crystal structure of lactose bound to galectin 2. Dashed lines indicate hydrogen bonds. (Adapted with permission from [178])... 

Putative recognition of 4-position hydroxyl of yv-acetyl-lactosamine through hydrogen-bonding interactions observed in the X-ray structure of galectin-1 from bovine spleen. (PDB entry Isit [12]). Other protein-ligand contacts are omitted for clarity... 

Fig. 11.1-2 (a) Structure of S-type lectin, galectin-3, bound to /V-acetyllactosamine and... 

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