Memantine Galantamine

Data from Product Information tacrine, donepezil, galantamine, memantine, and rivastigmine.34-38... 

Data from product Information for tacrine, donepezil, rivastigmine, galantamine, and memantine.34-38... 

Loveman, E., Green, C., Kirby, J., et al. (2006) The clinical and cost-effectiveness of donepe-zU, rivastigmine, galantamine and memantine for Alzheimer s disease. Health Technol. Assess., 10, 1-176. 

Wilcock G, Mobius HJ, Stoffler A, et al A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500). Int Clin Psychopharmacol 17 297-305, 2002 Wilcock G, Howe 1, Coles H, et al A long-term comparison of galantamine and donepezil in the treatment of Alzheimer s disease. Drug Aging 20 777-789, 2003... 

Grossberg G. T., Edwards K. R., and Zhao Q. (2006). Rationale for combination therapy with galantamine and memantine in Alzheimer s disease. J. Clin. Pharmacol. 46 17S-26S. 

Recent studies have reported that galantamine also improves the cognitive performance of patients with autism (Nicolson et al., 2006) and, unlike other cholinesterase inhibitors, decreases the negative symptoms in patients with schizophrenia (Schubert et al., 2006). Eor more severe Alzheimer s disease, memantine, an antagonist of N-methyl-D-aspartate (NMDA) receptors, has also been approved. A number of newer drugs undergoing clinical trials for Alzheimer s disease work by a variety of other mechanisms, although a common theme appears to be neuroprotection (Robertson and Mucke, 2006). 

Compiled from package inserts for Aricept (donepizil), Reminyl (galantamine)/ Namenda (memantine)/ Excelon (rivastigmine), and Cognex (tacrine)d° ... 

Van Dam D, Abramowski D, Staufenbiel M, De Deyn PP (2005) Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Psychopharmacology (Berlin) 177 381-390. 

Memantine does not appear to attenuate the anticholinesterase effects of donepezil, galantamine, or tacrine, nor affect the pharmacokinetics of galantamine or donepezil. 

An in vitro study in rats suggested that memantine does not attenuate the anticholinesterase effects of galantamine at therapeutic concentrations. A study in 15 healthy subjects found that the concurrent use of extended-re-lease galantamine 16 mg daily with memantine 10 mg twice daily for 12 days did not affect the pharmacokinetics of galantamine and generally did not increase the incidence of adverse effects, although dizziness may have been more common. ... 

Yao C, Raoufinia A, Gold M, Nye J, Ramael, Padmanabhan M, Walschap Y, Verfia he T, Zhao Q. Steady-state pharmacokinetics of galantamine are not affected hy additicxi of memantine in healthy subjects. J CUn Pharmacol (2005) 45,519-28. 

Koola, M. M., et al.. Potential role of the combination of galantamine and memantine to improve cognition in schizophrenia. Schizophr. Res., 2014. 

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