Galactocerebroside

Figure 14-12. Structure of galactosylcer-amide (galactocerebroside, R = H), and sul-fogalactosylceramide (a sulfatide, R = S04 ).

Krabbe s leukodystrophy AR Galactocerebroside- P-galactosidase Globoid cells contain galactocerebroside see text 1,2, Ch. 40... 

Figure 5.14 Freeze-etch electron micrograph of glycolipid nanotubes from 24 1 nonhydroxy galactocerebrosides (21) cryofixed from room temperature in water. Bar = 250 nm. Reprinted from Ref. 64 with permission of the Biophysical Society.

Structure of a neutral glycosphingolipid, galactocerebroside (R is a fatty acid hydrocarbon chain). 

Appreciable proportions of galactocerebrosides were found in the sea anemone Gyrostoma sp., the whole animal and its individual organs being studied the glycolipid was not, however, purified and studied in detail.75... 

Example 13.4. The result of a typical X-ray measurement is shown in Fig. 13.10 for a galactocerebroside [605], The plot on the left side shows the normalized reflected X-ray beam intensity versus the incident angle a for two different film pressures. The pressure-area isotherm is shown in the inset, together with the points of measurement a and b. On the right side are the extracted electron density profiles normal to the film surface taken at the same film pressures. At 0 A we find the monolayer surface (top of the alkyl chains), a depth of -40 A corresponds to pure water. In between is the film. The measurement is so sensitive that we even find two different electron densities within the monolayer. This is illustrated by the dashed boxes denoted by film 1 and film 2 (shown for curve b only) which represents the simplified electron density distribution in the so-called two-box model. A box is defined as a part in the film of a certain thickness where the electron density is constant. In the two-box model the film is divided into two layers. Film 1 represents the hydrocarbon tails, film 2 corresponds to the mean electron density of the head groups. 

Figure 13.10 Structure of galactocerebroside (top) and result of an X-ray reflectometry experiment with galactocerebroside monolayer on water [605].

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