Gabapentin neuralgia

Postherpetic neuralgia In adults with postherpetic neuralgia, gabapentin therapy may be initiated as a single 300 mg dose on day 1,600 mg/day on day 2 (divided... 

For postherpetic neuralgia, gabapentin can decrease concomitant opiate use... 

Response data for two studies were submitted to the FDA for approval for the treatment of postherpetic neuralgia (PHN). Both studies were randomized, double-blind, placebo-controlled, multicenter studies that evaluated the safety and efficacy of gabapentin administered orally three times a day, compared with placebo. In both studies, the patients were titrated to their final-treatment dose by the end of either week... 

Gabapentin is the most commonly used antiepilepsy drug in this setting phenytoin (which raises the threshold of nerve cells to electrical stimulation) or sodium valproate are used for resistant neuralgias. 

A 60-year-old woman with post-herpetic neuralgia developed asterixis after having taken gabapentin for 4 days (18). The authors proposed that the mechanism was GABAergic. 

Gabapentin, an anticonvulsant that stimulates gamma-aminobutyric acid (GABA) receptors, is used as an adjunctive therapy in treattnent of partial seizures with or without secondary generalization in patients older than 12 years of age with epilepsy adjunctive therapy for partial seizures in children 3 to 12 years of age and for management of postherpetic neuralgia in adults (see Figure 53). 

Gabapentin Neurotin Aclonium Anticonvulsant/ analgesic CNS depressant mp 164 °C Treatment of neuralgia, pain from shingles, migraine, and epilepsy H2N COOH c5... 

Wallace MS, Irving G, Cowles VE. Gabapentin extended-release tablets for the treatment of patients with postherpetic neuralgia a randomized, double-blind, pfacebo-controlled, multicentre study. Clin Drug Investig 2010 30(11) 765-76. 

Post-herpetic neuralgia (PHN) gabapentin therapy may be initiated as a single 300-mg dose on day 1,600 mg/day on day 2 (divided BID), and 900 mg/day on day 3 (divided TID). The dose can subsequently be titrated up as needed for pain relief up to a target daily dose of 1800 mg (divided TID). In clinical studies, efficacy was also demonstrated over a range of doses... 

Rice AS, Maton S. Postherpetic Neuralgia Study Group. Gabapentin in postherpetic neuralgia a randomized, double blind, placebo controlled study. Pflm2001 94(2) 215-224. 

Rowbotham M, Harden N, Stacey B, et al. Gabapentin for the treatment of postherpetic neuralgia a randomized controlled trial. JAMA 1998 280(21) 1837-1842. 

O Connor AB, Noyes K, Holloway RG. A cost-effectiveness comparison of desipramine, gabapentin, and pregabalm for treating postherpetic neuralgia. / Am Geriatr Soc 2007 55(8) 1176-1184. 

A 44-year-old man with post-herpetic neuralgia was given amitriptyline and gabapentin... 

Irving G. Once-daily gastroretentive gabapentin for the management of postherpetic neuralgia an update for clinicians. Ther Adv Chronic... 

---