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GABAa receptors, activation

Figure 11.5 Chloride distribution and the GABAa response. The change in membrane voltage (Fm) that results from an increase in chloride conductance following activation of GABAa receptors is determined by the resting membrane potential and the chloride equilibrium potential (Fci)- (a) Immature neurons accumulate CF via NKCC, while mature neurons possess a Cl -extruding transporter (KCC2). (b) In immature neurons GABAa receptor activation leads to CF exit and membrane depolarisation while in mature neurons the principal response is CF entry and h5q)erpolarisation. This is the classic inhibitory postsynaptic potential (IPSP)... Figure 11.5 Chloride distribution and the GABAa response. The change in membrane voltage (Fm) that results from an increase in chloride conductance following activation of GABAa receptors is determined by the resting membrane potential and the chloride equilibrium potential (Fci)- (a) Immature neurons accumulate CF via NKCC, while mature neurons possess a Cl -extruding transporter (KCC2). (b) In immature neurons GABAa receptor activation leads to CF exit and membrane depolarisation while in mature neurons the principal response is CF entry and h5q)erpolarisation. This is the classic inhibitory postsynaptic potential (IPSP)...
Zhang, SJ and Jackson, MB (1995) GABAa receptor activation and the excitability of nerve terminals in the rat posterior pituitary. /. Physiol. (Lond.) 483 583-595. [Pg.250]

A deficit in as GABAa receptor activation is associated with an improved hippocampal performance in temporal and spatial memory tasks (see above)... [Pg.239]

Sanna, E., Talani, G., Busonero, F., Pisu, M. G., Purdy, R. H., Serra, M., and Biggio, G. (2004). Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. [Pg.93]

Most S-H drugs facilitate the actions of GABA, a major inhibitory transmitter in the CNS, GABAa receptor activation leads to increased Cl- ion influx GABAb receptor activation causes increased efflux of K+. Both mechanisms result in membrane hyperpolarization. [Pg.145]

Benzodiazepines and agents that enhance chioride channei/GABAA receptor activity... [Pg.74]

Agents that suppress chloride channel/GABAA receptor activity (cause anxiety)... [Pg.76]

A Preparation for Studying Subhippocampai GABAa Receptor Activity... [Pg.49]

Here we will describe a modification of the synaptoneurosome preparation method that permits the isolation of synaptoneurosomes from restricted brain areas, as demonstrated by the isolation of synaptoneurosomes from the CAi 3 area and DG, respectively. Subsequent filtration and low-speed centrifugation of subhippocampal homogenates yield viable synaptoneurosomal preparations within 45 mm after tissue homogenization. In addition, we will describe an assay for muscimol-stimulated Ch-uptake as a measure of GABAA-receptor activity in these subhippocampal synaptoneurosomal preparations. [Pg.50]

See other pages where GABAa receptors, activation is mentioned: [Pg.634]    [Pg.153]    [Pg.518]    [Pg.284]    [Pg.501]    [Pg.486]    [Pg.487]    [Pg.506]    [Pg.506]    [Pg.512]    [Pg.377]    [Pg.432]    [Pg.35]    [Pg.30]    [Pg.58]    [Pg.649]    [Pg.57]    [Pg.4006]    [Pg.4707]   
See also in sourсe #XX -- [ Pg.174 ]



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Active receptor

GABAa receptors

GabaA

Receptor activation

Receptor activity

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