GABA receptors oocyte

GABA receptor Apigenin Apigenin, epigallocatechin gallate Rat cerebellar granule cells Xenopus laevis oocytes Inhibition Stimulation Avallone et ah, 2000 Campbell et ah, 2004... 

GABA receptor, a target for several classes of insecticides, consists of two subunits, each with four transmembrane helices as determined from cloning and sequence analysis (641. Expression in Xenopus oocytes requires mRNA from only one of the subunits (651. Dieldrin resistant cockroaches were found to have reduced specific binding of picrotoxinin, which acts on the GABA receptor chloride ion channel (661. 

Rdl orthologs have since been cloned from many other insect species and, when heterologously expressed in the Xenopus oocyte expression system or in cell lines, give membrane receptors that behave like insect GABA receptors. Rdl... 

Expression studies in Xenopus oocytes or transfected cell lines originally suggested that functional GABA-activated chloride channels could be formed by receptor subunits of each class in isolation. However, much better expression occurs with two or more subunit types in combination and it is likely that most native receptors contain at least three different subunits. Co-expression of a and /I subunits results in the assembly of... 

The DNA for the GABAA-receptor channel has been translated to the respective RNA by in vitro transcription of the cDNAs (for a and P) inserted into plasmids. The two RNAs, when injected together into Xenopus oocytes, produced GABA-sensitive CP-currents [3]. 

Waeber C, Hoyer D, Palacios JM S-HTj receptors in the human brain audioradiographic visualization. Neuroscience 31 393-400, 1989 Wafford KA Ethanol sensitivity of the GABA A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma2L subunit. Neuron 7 27-33, 1991... 

J. Hossain, K. Hamamoto, H. Aoshima, Y. Hara (2002) Effects of tea components on the response of GABA(A) receptors expressed in Xenopus oocytes. J. Agric. Food Ghent., 50,... 

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