GABA molecular biology

Chebib, M and Johnston, GA (2000) GABA-Activated ligand gated ion channels medicinal chemistry and molecular biology. J. Med. Chem. 43 1427-1447. 

Molecular Neuropharmacology Strategies and Methods is intended to bridge the gap between molecular biology and advanced chemistry. In addition, it attempts to include information about x-ray crystallographic analyses whenever available. This book discusses interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. 

Second-order rate constants for MTSEA-, MTSET-, and MTSES-modification of residues within the loop D region of the GABA-binding site. Second-order rate constants (IC2) represent the mean standard deviation. NR, no reaction. The free solution rates were reported by Karlin and Akabas (1998) and reflect the rates of MTS reaction with 2-mercaptoethanol. Adapted from Holden and Czajkowski (2002) with permission from the American Society of Biochemistry and Molecular Biology... 

Barnard EA. The molecular biology of GABA receptors and their structural determinants. In Biggio C, Sanna E, and Costa E (eds.). GABAa Receptors and Anxiety From Neurobiology to Treatment. 

Burns G, Herz A, Nikolarakis KE Stimulation of hypothalamic opioid peptide release by lithium is mediated by opioid autoreceptors evidence from a combined in vitro, ex vivo study. Neuroscience 36 691-697, 1990 Burt DR, Kamatchi GL GABA A receptor subtypes from pharmacology to molecular biology. EASEB J 5 2916-2923, 1991... 

Hosie AM, Aronstein K, Sattelle DB, ffrench-Constant RH (1997) Molecular Biology of Insect Neuronal GABA Receptors. Trends Neurosci 20 578... 

Olsen, R.W. and Tobin, A.J. (1990) Molecular biology of GABA receptors. FASEB. Journal, 4, 1812-1823. 

Barnard EA, Darlison MG, Seeburg P (1987) Molecular biology of the GABA receptor the receptor/channel superfamily. TINS, 10, 502. 

Advances in the molecular biology and pharmacology of the neurotransmitter, GABA, have established there is considerable heterogeneity in GA-BAa receptors, the receptors known to be modulated by all the clinically effective benzodiazepine anxiolytics. The consequent surge of activity to find anxiolytic agents which are more selective and possess fewer side-effects than the early benzodiazepines has led to the synthesis of a variety of novel structures. One such series of pyrido[l,2-a]benzimidazoles is described in Chapter 4. 

GABA-activated ligand gated ion channels medicinal chemistry and molecular biology 00JMC1427. 

P. Krogsgaard-Larsen, P. Jacobsen, E. Falch, H. Hjeds (1982). GABA-agonists chemical, molecular, pharmacologic and therapeutic aspects. In A. M. Creighton, S. Turner (Eds.). The Chemical Regulation of Biological Mechanisms. London Royal Society of Chemistry. 

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