GABA-ergic receptor

Stelzer, A, Slater, NT and Bruggencate, G (1987) Activation of NMD A receptors blocks GABA ergic innervation in an in vitro model of epilepsy. Nature 326 698-701. 

Table 9.1. Effects of GABA-ergic agents on the GABAa receptor and anxiety.

Anatomical and pharmacological studies have both indicated that the two major transmitter systems within the brain are the inhibitory GABA ergic and the excitatory amino acid (EAA) pathways [264]. At least four different receptors mediate the action of EAA, they are named according to the most selective li-... 

Another receptor system with which neurosteroids interact is the N-methyl-D-aspartate [NMDA] receptor. Pregnenolone sulfate acts as a positive allosteric modulator of the NMDA receptor, in analogy to GABA-ergic effects, by increasing the frequency and duration of NMDA-activated channel opening [Bowlby 1993 Irwin et al. 1992 Wu et al. 1991]. 

It belongs to azapirones which is chemically and pharmacologically distinct class. It acts as a partial agonist at serotonin and dopamine receptors and having no hypnotic and sedative action. It does not interact with benzodiazepine receptor or modify GABA-ergic transmission. 

The possibility that dopamine regulates neostriatal GABA-ergic function receives no support from in vitro superfusion experiments determining the release of [3HJ-GABA from slices of rat neostriatum (5 3). The D-2 receptor agonist RU 24926 is... 

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