A-Receptor, blocking

Stelzer, A, Slater, NT and Bruggencate, G (1987) Activation of NMD A receptors blocks GABA ergic innervation in an in vitro model of epilepsy. Nature 326 698-701. 

Top Effects of phentolamine, an a-receptor-blocking drug, on blood pressure in an anesthetized dog. Epinephrine reversal is demonstrated by tracings showing the response to epinephrine before (middle) and after (bottom) phentolamine. All drugs given intravenously. BP, blood pressure HR, heart rate. 

Co-dergocrine has an a-receptor blocking and a centrally depressive effect. As distinct... 

Savaki, H. E., McCulloch, J., Kadekaro, M., and Sokoloff, L., 1982c, Influence of a-receptor blocking agents upon metabolic activity in nuclei involved in central control of blood pressure. Brain Res. 233 347-358. 

Prazosin (VIII) and three other diaminoquinazolines lowered systolic blood pressure in h3q>ertensive dogs-- Prazosin at doses as low as 20 y/kg., p.o. In cats, the pressor effect of epinephrine, but not that of angiotensinamide, was reduced or reversed. The conq)ounds appear to inhibit periph-erial sympathetic activity but do not have conventional ganglionic or a-receptor blocking actiont Prazosin was effective clinically at oral doses of 3-21 mg., and reduced standing more than supine blood pressure with a short dvira-tion of actiont ... 

---