GABA and Depression

Depression is one of the most common conditions in the UK, affecting one in five people at some stage in their life. The World Health Organization (WHO) estimates that by 2020 depression will be the biggest global health concern after chronic heart disease. Depression occurs in children, adolescents, women in menopause, the elderly, or those with mental disorder, especially in menopause. - The symptom of depression in menopause will cause mood obstacles about 10 years later. -  

Evidence from preclinical and clinical data suggests that GABA plays a role both in the pathophysiology of depression and bipolar disorder and in the mechanisms of action of antidepressant agents. - Low GABA concentrations and receptor activity in the brain cause depression, palpitation, insomnia, learning disorders, and memory failure. - GABA concentration in the CSF is inversely correlated with the severity of depression.  

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