Future Directions for UHP-MDLC

One of the major trends to be anticipated is greater availability of instrumentation that can be used to perform multidimensional separations at ultrahigh pressures. Some instrument makers have recently introduced LC pumps capable of operating at pressures up to 15,000 psi. As time progresses, ultrahigh pressure separations are likely to become more routine and the pressure limit of commercial instruments is likely to increase 

Bushey, M.M., Jorgenson, J.W. (1990). Automated instrumentation for comprehensive two-dimensional liquid chromatography of proteins. Anal. Chem. 62, 161-167. 

Cortes, H.J. (1990). Multidimensional Chromatography Techniques and Applications. Marcel Dekker, Inc., New York. 

(1978). Two-dimensional column liquid chromatographic technique for resolution of complex mixtures. J. Chromatogr. 149, 561-569. 

Giddings, J.C. (1987). Concepts and comparisons in multidimensional separation. J. High. Resolut. Chromatogr. Chromatogr. Commun. 10, 319-323. 

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