Further Application Examples

As a further application of the reaction, the conversion of an endocyclic double bond to an c.xo-methylene is possible[382]. The epoxidation of an cWo-alkene followed by diethylaluminum amide-mediated isomerization affords the allylic alcohol 583 with an exo double bond[383]. The hydroxy group is eliminated selectively by Pd-catalyzed hydrogenolysis after converting it into allylic formate, yielding the c.ro-methylene compound 584. The conversion of carvone (585) into l,3-disiloxy-4-methylenecyclohexane (586) is an example[382]. 

At this point we should also recall another application of the already mentioned Bernal model of amorphous surface. Namely, Cascarini de Torre and Bottani [106] have used it to generate a mesoporous amorphous carbonaceous surface, with the help of computer simulation and for further application to the computer simulation study of adsorption. They have added a new component to the usual Bernal model by introducing the possibility of the deletion of atoms, or rather groups of atoms, from the surface according to some rules. Depending on the particular choice of those rules, surfaces of different porosity and structure can be obtained. In particular, they have shown examples of mono- as well as pohdispersed porous surfaces... 

Further links exist between the PIF concept and topics considered in previous chapters. In Chapter 2 the sequential model developed by Rasmussen to represent the error process from its initiator to its consequences was described (Figure 2.9). In this process, the PIFs were shown as being involved in both the initiating event and the internal error mechanisms. In the application example of the model in Appendix 2C, the PIF which constituted the initiating event was the distracting environment, and poor ergonomics of the panel was a PIF which influenced the internal error mechanism. 

These same diamine materials find further application in, for example, formulations for mussel and barnacle control in large once-through, condenser cooling systems, as corrosion inhibitors and biostats for hydrostatic testing of oil and gas pipelines, and as corrosion inhibitors in food industry retort cookers. 

The third contribution deals with an rather old synthetic electroorganic reaction, Kolbe-Electrolysis. However, recently this reaction has found so many interesting and important new applications, for example in the synthesis of natmully products or the generation of versatile, even enatiomerically pure, synthetic building blocks, that it was nec sary to cover these new developments in a review. As these reactions are usually very easy to perform without expensive equipment, it is hoped that further applications in many laboratories will be initiated by this article. 

The following examples illustrate further applications of the lUPAC guidelines ... 

As an example, a compact high-throughput turbulent flow reactor/mixer/heat exchanger was used for various applications, including polymer and rubber manufacture [50]. Further applications refer to emulsification and intensified heat exchange. 

Further applications of this approach are given in the simulation examples, ENZSPLIT and ROD. 

In an effort to develop easy-to-use ketoreductase toolbox , we have surveyed the activity and enantioselectivity of a collection of ketoreductases (KRED) from various sources toward the reduction of a variety of ketones [90,91]. These studies served as a useful guideline for developing enzymatic processes for the production of optically pure chiral alcohols. For example, several chiral chlorohydrins of pharmaceutical importance were synthesized in both enantiomeric forms using the enzymes in this ketoreductase collection (Table 7.2) [92]. Further applications of this collection and other commercially available ketoreductases can be found in a recent review [9]. 

Further applications of microwave-assisted reductive aminations are shown in Schemes 6.150 and 6.151. In the example highlighted in Scheme 6.150, Baran and... 

Although the use of the number of protons and neutrons to predict stability is straightforward, there are further applications of the principles discussed that are useful also. For example, consider the following cases ... 

This dynamic approach to equilibrium method is used in later examples to illustrate its further application to the solution of complex steady state problems. 

In a further application of MI-SPE, theophylline could be separated from the structurally related caffeine by combining the specific extraction with pulsed elution, resulting in sharp baseline-separated peaks, which on the other hand was not possible when a theophylline imprinted polymer was used as stationary phase for HPLC. A detection limit of 120 ng mb1 was obtained, corresponding to a mass detection limit of only 2.4 ng [45]. This combination of techniques was also used for the determination of nicotine in tobacco. Nicotine is the main alkaloid in tobacco and is the focus of intensive HPLC or GC analyses due to its health risk to active and passive consumers. However, HPLC- and GC-techniques are time-consuming as well as expensive, due to the necessary pre-purification steps required because the sample matrices typically contain many other organic compounds besides nicotine. However, a simple pre-concentration step based on MI-SPE did allow faster determination of nicotine in tobacco samples. Mullett et al. obtained a detection limit of 1.8 jig ml 1 and a mass detection limit of 8.45 ng [95]. All these examples demonstrate the high potential of MI-SPE to become a broadly applicable sample pre-purification tool. 

Chapter 10 provides an exhaustive description of how these techniques can be applied to a large number of industrial alloys and other materials. This includes a discussion of solution and substance databases and step-by-step examples of multi-component calculations. Validation of calculated equilibria in multi-component alloys is given by a detailed comparison with experimental results for a variety of steels, titanium- and nickel-base alloys. Further selected examples include the formation of deleterious phases, complex precipitation sequences, sensitivity factor analysis, intermetallic alloys, alloy design, slag, slag-metal and other complex chemical equilibria and nuclear applications. 

In the third chapter Wheatley and Linton describe new developments in the remarkable chemistry of aluminum and oxygen. While compounds featuring an aluminum-oxygen bond find widespread utility (as catalyst supports and co-catalysts, for example) there is still a great deal that is not understood in how these compounds form. This chapter provides the necessary basic information upon which further applications may be developed. 

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