Furosemide Digoxin

In vitro plasma protein binding of donepezil is 96%, mainly to albumin (75%). Plasma protein binding competition with furosemide, digoxin and warfarin showed that... 

Noninterfering chloral hydrate, chlorpromazine, furosemide, digoxin, promethazine... 

There is a risk of acute renal failure when iodi-nated contrast material that is used for radiological studies is administered with metformin. Metformin therapy is stopped for 48 hours before and after radiological studies using iodinated material. Alcohol, amiloride, digoxin, morphine, procainamide, quini-dine, quinine ranitidine, triamterene, trimethoprim, vancomycin, cimetidine, and furosemide all increase the risk of hypoglycemia. There is an increased risk of lactic acidosis when metformin is administered with the glucocorticoids. 

A 65-year-old female receives digoxin and furosemide for GIF After several months, she develops nausea and vomiting. Serum K+ is 2.5 mFq/L. Electrocardiogram (EKG) reveals an AV conduction defect. What cellular effect is causing these new findings ... 

A 76-year-old female with an eight-year history of CHF that has been well controlled with digoxin and furosemide develops recurrence of dyspnea on exertion. On physical examination, she has sinus tachycardia, rales at the base of both lungs, and 4+ pitting edema of the lower extremities Which agent could be added to her therapeutic regimen ... 

Digoxin Furosemide Hypokalemia may increase risk for digitalis-intoxication... 

A 75-year-old man has inoperable coronary artery disease with an EF of 31%. He is receiving digoxin, furosemide, and an ACE inhibitor. He is unable to walk more than 50 feet on flat ground before getting short of breath (dyspnea on exertion at 50 feet). His heart rate at rest is 85 beats per minute and his blood pressure while seated is 130/85. His neck veins are flat carotid upstrokes are normal lungs are clear and heart examination reveals no murmurs, gallops, or rubs. His extremities reveal no cyanosis, clubbing, or edema. The remainder of the physical examination is unremarkable. What is your next therapeutic option ... 

Drugs that can precipitate lactic acidosis in patients taking metformin include ACE inhibitors, thiazide diuretics, NSAIDs, and drugs such as furosemide, nifedipine, cimetidine, amiloride, triamterene, trimethoprim, and digoxin, which are all secreted in the renal tubules, compete with metformin, and can contribute to increased plasma metformin concentrations (76). 

Examples of specific drugs used in the treatment of chronic heart failure include digitalis glycosides (e.g., digoxin, positive inotropic agent), diuretics (hydrochlortiazide and furosemide), and vasodilators (nitrates such as nitroglycerin, ACE inhibitors, such as captopril, and hydralazine). 

Figure 6.17 The classification of 42 drugs in the (solubility-dose ratio, apparent permeability) plane of the QBCS. The intersection of the dashed lines drawn at the cutoff points form the region of the borderline drugs. Key 1 acetyl salicylic acid 2 atenolol 3 caffeine 4 carbamazepine 5 chlorpheniramine 6 chlorothiazide 7 cimetidine 8 clonidine 9 corticosterone 10 desipramine 11 dexamethasone 12 diazepam 13 digoxin 14 diltiazem 15 disopyramide 16 furosemide 17 gancidovir 18 glycine 19 grizeofulvin 20 hydrochlorothiazide 21 hydrocortisone 22 ibuprofen 23 indomethacine 24 ketoprofen 25 mannitol 26 metoprolol 27 naproxen 28 panadiplon 29 phenytoin 30 piroxicam 31 propanolol 32 quinidine 33 ranitidine 34 salicylic acid 35 saquinavir 36 scopolamine 37 sulfasalazine 38 sulpiride 39 testosterone 40 theophylline 41 verapamil HC1 42 zidovudine.

A 70 year old alcoholic male with poor dental hygiene is to have his remaining teeth extracted for subsequent dentures. He has mitral valve stenosis with mild cardiac insufficiency and is being treated with capto-pril, digoxin and furosemide. The dentist decides that his medical history warrants prophylactic antibiotic therapy prior to the procedure and prescribes ... 

A. The furosemide was increasing her urine output and thereby increasing the elimination of digoxin from the blood. 

---