Fungi Penicillium roqueforti

Compounds 8-11 belonged to the bisabolane family of sesquiterpenes. Bisabolane sesquiterpenes are not typical microbial metabolites. Most compounds of this skeletal class have been isolated from numerous terrestrial plants, a basidiomycete [101], sponges [102-103], octocoral [104, 105], and red algae [106], To our knowledge there have been two reports of bisabolanes from fungi. The first report in 1989 was of a mycotoxin from Fusarium sambucinum [107], More recently, mass spectral analysis of the volatile constituents of toxigenic Penicillium roqueforti strains yielded P-bisabolene [108]. 

Penicillium roqueforti Fungi Bread. 14 days, 25°C 30.000 ++ + Suhr and Nielsen (2003)... 

Neurotoxic mycotoxins of the indole alkaloid type from many mold fungi of the genus Penicillium. e.g., P. roqueforti. P cyclopium, P. commune, P crustosum, P. chrysogenum, P. griseofulvum. The R. occur in blue cheese and cotton seeds and have also been found in beer. The main alkaloid is R. C. R. can lead to abortions in animal experiments. Today, toxin-free strains are used for the production of cheese. R. C and R. D are formed from tryptophan, histidine (diketopipera-zine part) and mevalonic acid. R. A and R.B are alkaloids of the clavine type (see ergot alkaloids). The LD50 for mice (i.p.) is 15 mg R.C/kg. 

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