Fungal infections, prophylaxis against

Prophylaxis against fungal infections should also be commenced with daily oral itraconazole or fluconazole. If fever develops and the individual has had a poor white blood cell count for more than 2-3 weeks, intravenous amphotericin B or the liposomal formulation, Ambisome, should be given. 

In the case of opportunistic candidal infections in the immunocompromised patient, no prophylactic drugs have been shown to be effective. Prophylaxis against other fungi may be effective in some instances, including suppression of cryptococcal meningitis in AIDS patients with fluconazole. However, prophylactic use of azoles may be contributory to the development of fungal resistance. The answer is (E). 

Efficacy In other conditions The clinical efficacy in the treatment of stromal keratitis and uveitis caused by herpes simplex or ophthalmic infections caused by vaccinia virus and adenovirus, or in the prophylaxis of herpes simplex virus keratoconjunctivitis and epithelial keratitis has not been established by well-controlled clinical trials. Not effective against bacterial, fungal, or chlamydial infections of the cornea or trophic lesions. 

---