Functionalization oxygenated intermediates

Wullner U., Seylfied J., Groscurth P., Beinroth S., Winter S., Gleichmann M., Heneka M., Loschmann P., Schulz J. B., Weller M., and Klockgether T. (1999). Glutathione depletion and neuronal cell death the role of reactive oxygen intermediates and mitochondrial function. Brain Res. 826 53-62. 

McCarthy MB, White RE (1983) Functional differences between peroxidase compound I and the cytochrome P-450 reactive oxygen intermediate. J Biol Chem 258 9153-9158... 

Ceruloplasmin binds eight copper atoms per molecule and is of an intense blue colour. The coding gene is localized on chromosome 3. (396) Ceruloplasmin is the most important transport protein for copper in circulating blood (about 75-95% binding capacity). Another important function of this protein is the catalysis of oxidative metabolic reactions it also possesses antioxida-tive features for the elimination of reactive oxygen intermediates. (s. tab. 3.25) The normal value in serum is 20-35 mg/dl. 

The effects of fosfomycin on several indices of neutrophil function have been studied in vitro (6). Phagocytosis was unaffected but there was enhanced bactericidal ability, increased intracellular calcium concentrations, raised extracellular reactive oxygen intermediate production, and reduced chemotaxis fosfomycin did not affect intracellular oxygen intermediate production or chemokinesis. 

Fig.6 shows PO yield over 8 wt % Au/TiOj/SiO, as a function of time. The catalytic activity of Au/TiOj/SiOj catalyst is not stable. Water is continuously formed during the oxidation of propylene and the oxygenated intermediates may block the active sites and depress the adsorption of propylene on the surface of the catalyst. MCM materials have hydrophobic character and Ti-MCM preferentially adsorbs less polar olefin molecules. This decreases the competition from water and probably avoid the accumulation of the oxygenated intermediates to lead to more stable catalytic activity. 

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