Fumaria officinalis, protopines

Even given that the formation of (-) reticuline cannot be blocked, there may be opportunities to block the biochemical sequences leading to thebaine, or even to splice in mechanisms leading to nonaddictive alkaloids produced from (-) reticuline by other plants—for example, berberine ex Hydrastis canadensis or protopine ex Fumaria officinalis. 

H. Protopine Alkaloids.—Alkaloids of Fumaria officinalis which were difficult to separate by partition chromatography and counter-current distribution were separated by column chromatography.190... 

Recent sources of known protopine alkaloids are Argemone albijiora, A. mexicana, growing in Vietnam and Sudan, U.S.S.R., and North Vietnam, A. ochroleuca, and Corydalis ambigua. Protopine and cryptopine as well as six as yet unidentified alkaloids have been isolated from Fumaria officinalis. The yield of alkaloids from this species as a function of the drying technique has been studied. Papaver urbanianum has been shown to yield muramine and protopine. Apparently, no structurally new protopine alkaloids have been isolated during the past year nor has any synthetic work been carried out. 

Protopine, cryptopine, corydamine, sinactine, (+)-adlumine, (—)-a-hydrastine, (+)-corlumine, (—)-fumarophycine, (-)-O-methylfumarophycine, (+)-parfumine Fumaria officinalis and phytopreparations NACE 60 mM ammonium acetate in acetonitrile-methanol (9 1) and 2.2 M acetic acid ESI-MS [75]... 

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