Fucoidan weight

Table 1. Effects of fucoidan on body, thymus, spleen and adipose tissue weight in sarcoma 180-bearing mice1...

Luyt, C. E., Meddahi-Pelle, A., Ho-Tin-Noe, B., Colliec-Jouault, S., Guezennec, J., Louedec, L., Prats, H., Jacob, M. P., Osborne-Pellegrin, M., and Letourneur, D. (2003). Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hin-dlimb ischemia. /. Pharmacol. Exp. Ther. 305, 24. 

Wang, J., Zhang, Q., Zhang, Z., Song, H., and Li, P. (2010). Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. Int.. Biol. Macromol. 46, 6-12. 

The therapeutic potential of very low-molecular-weight fucoidans for the prevention of blood restenosis has also been demonstrated in animal models (Deux et al., 2002). A restenosis is often seen after the introduction of a balloon into an artery that has been narrowed by a plaque of atheroma, in order to restore the caliber of the artery (angioplasty operation) the insertion of a stent (a metal endoprosthesis) into the artery then maintains its integrity. 

Because of their ability to interact with growth factors, and especially with basic fibroblast growth factor (bFGF), fucoidans have potential effects in the context of therapeutic angiogenesis. The pro-angiogenic properties of low-molecular-weight fucoidans were also studied in vitro (Matou et al, 2002 Chabuteta/., 2003), and also in vivo in a model of critical muscle ischemia of the lower limbs in rats (Luyt et al, 2003). 

Chabut D Fisher, A.-M., Colliec-Jouault, S., Laurendeau, I., Matou, S Le Bonniec, B and Helley, D. (2003) Low molecular weight fucoidan and heparin enhance the basic fibroblast growth factor-induced tube formation of endothelial cells through heparan sulfate-dependent a6 over-expression. Mol. Pharmacol., 64, 696-702. 

Colliec, S., Boisson-Vidal, C., and Jozefonvicz, J. (1994) A low molecular weight fucoidan fraction from the brown seaweed Pdvetia canaliculata. Phytochemistry, 35, 697-700. 

Colliec-Jouault, S., Millet, J., Helley, D., Sinquin, C and Fisher, A.-M. (2003) Effect of low-molecular-weight fucoidan on experimental arterial thrombosis in the rabbit and rat J. Thromb. Haemost., 1, 1114-1115. 

Yang, C Chung, D Shin, IS Lee, HY Kim, JC Lee, YJ You, SG. Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida. International Journal of Biological Macromolecules, 2008, 43, 433-437. 

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