From Warburgia ugandensis

Scheme 3 shows the synthesis of (-)-cinnamodial (ugandensidial) (18), the warburganal-related dialdehyde, from the drimenol (2) [25]. Cinnamodial also has a bitter taste [3], and possesses antimicrobial, antifeedant, piscicidal and antihelmintic activities [3, 4]. Cinnamodial (18) has been simultaneously isolated from Cinnamosma fragrans [26] and from Warburgia ugandensis [27], and then from other plants [4],... 

Isol. from Warburgia ugandensis and Canella winteriana. Antifeedant. Cryst. Mp 127-128°. [a] -193° (c, 0.2 in CHCI3). 

Muzigadial (58), a drimane sesquiterpene isolated from the bark of East African plant Warburgia ugandensis and W. stuhlmanii [24,25] shows potent activity against the African armyworms. In addition, muzigadial (58) exhibits a broad antibiotic spectrum as well as helicocidal activity [24]. 

Further results from this screening programme were the isolation and determination of polygodial (9), warburganal (10) and ugandensidial (11) from the bark of the plants Warburgia stuhlmannii and W. ugandensis (Kubo and Nakanishi, 1977 Nakanishi and Kubo, 1977 Meinwald et al., 1978). 

---