Friend Manufacturing

A highly optimized and concise large-scale synthesis of a purine bronehodilator was developed by the Astra Production Chemical company from Sweden [6], Supplies for the initial biological studies were generated by the medieinal ehemistry route shown in Scheme 5. The overall yield was about 14%, which was improved in the environmentally friendly manufacturing process to about 51% (Seheme 6 and Scheme 7). 

With no further purification. The commercial route was further optimized to minimize waste and maximize solvent recovery. Pfizer was awarded the Crystal Faraday Award for Green Chemical Technology by the Institute of Chemical Engineers in recognition of the environmentally-friendly manufacturing of sildenafil. 

Long-term goals consist of step-by-step implementation of environmentally friendly manufacturing, developing "innovative products." The ultimate outcome is design of innovative food products like functional foods, which can open new markets and meet green productivity objectives. 

The law in Germany on Material Cycles and Waste Materials (1996) and on End-of-Life Vehicles (2002) attaches particular importance to material cycles and to producers being responsible for their products in the sense of eco-friendly manufacture. On a global scale, it can be seen that various governments put more or less emphasis on such legal regulations. The highest-developed countries should be pioneers in this respect. So what does product responsibility mean, and how can textiles be produced in accordance with it Producers should... 

In the spring of 1S>41 the CWS contracted with the F. E. Myers and Brothers Co., Ashland, Ohio, a manufacturer of pumps and orchard sprayers, for six power driven models. On the basis of these models, which the company delivered in June 1S>41, the CWS wrote specifications for the power driven decontaminating apparatus. After the outbreak of war the Myers Co. continued to manufacture the item. In March 1942 two additional companies, Friend Manufacturing Co., Gasport, N.Y., and John Bean Manufacturing Co., Lansing, Mich., got into production. Later A. B. Farquhar of York, Pa., was awarded a contract. These companies found the item so difficult to manufacture that the CWS Inspection Division deemed it advisable first to approve numerous changes in the specifications and eventually to authorize a performance-type specification for the item. 

---