Monopril - Fosinopril sodium

A third class of ACE inhibitors is represented by fosinopril sodium (Monopril , Bristol-Myers Squibb), a phosphinate ester which hydrolyzes in vivo to the phosphinic acid. 

Fosinopril sodium (Monopril) by ICP-MS. Journal of Pharmaceutical and Biomedical Analysis 13 879-883. 

USAN Fosinopril sodium Trade name Monopril ... 

Another example using a prochiral acetate and asymmetric hydrolysis was described by the Bristol-Myers Squibb group for an intermediate in the synthesis of Monopril (fosinopril sodium) (41), an ACE inhibitor (Scheme 19.23). The prochiral substrate 42 was hydrolyzed both when R = phenyl or cyclohexyl to the corresponding (S)-(-)-monoacetate 43. The reaction was carried out in a 10% toluene biphasic system with either PPL or Chromobacterium viscosum lipase. The cyclohexyl monoacetate was obtained in 90% yield with an optical purity of 99.8%.107 195... 

Fosinopril Sodium. Fosinopril sodium. (4,S)-4-cyclo-hexyl-1 -I I l(/fS)-1 -hydroxy-2-methylpropoxy (4-phenyl-bu-(yl)phosphinyl acetyl -(.-proline sexlium salt (Monopril). is a phosphorus-containing ACE inhibitor. It is inactive but. serves us a prodrug. being completely hydrolyzed by intestinal and liver en/ymes to (he active diacid fosinoprilat. 

Monopril (Fosinopril sodium). Bristol-Myers Squibb Company. US Prescribing information, July 2003. 

Monopril fosinopril. monosulfiram [ban] (sulfiram [inn]) is an ethylthiocarbonic acid derivative with ANTIFUNGAL properties and can be used as parasiticide and fungicide, montelukast [ban, inn] (montelukast sodium [usan] Singulair ) is a chloroquinolinyl derivative, a (LTD ) LEUKOTRIENE receptor antagonist, which can be used as an ANTIASTHMATIC. 

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