Foscamet sodium

QHijOjP 122-52-1) see Foscamet sodium Gesirinone 7-O-triethylsilylbaccatin III (C,7H520 Si 115437-21-3) see Paclitaxel 4-triethylsilyl 3-butyn-l-ol triethylsilyl ether (C 4Hj40Si2 160194-28-5) see Rizatriptan benzoate triethylsilyl chloride... 

Foscamet sodium should not be mixed with any intravenous infusion drug, since it interacts with glucose- and calcium-containing solutions and sodium, ganciclovir, certain antibacterials, amphotericin, pentamidine isethionate, and trimetrexate.18 Care must be taken to avoid inhalation and exposure of the skin to zalcitabine powder. 

Iyer RP, Phillips LR, Biddle JA, Thakker DR, Egan W, Aoki S, Mitsuya H (1989) Synthesis of acyloxyalkyl acylphosphonates as potential prodmgs of the antiviral, trisodium phosphonoformate (foscamet sodium). Tetrahedron Lett 30 7141-7144... 

Foscamet sodium (Fig. 23.20) mimics pyrophosphate and inhibits the binding of nudeoside triphosphates to DNA polymerase. Thus it has a relatively broad spectrum of activity, but is used to treat CMV and herpes in AIDS patients. Since it has a different mode of action from dmgs such as addovir, it can be used in combination with them to increase the effectiveness of treatment. Since it forms insoluble salts with bases it is incompatible with basic drugs such as pentamidine and vancomydn, which may be used to treat secondary infections in AIDS. 

Foscamet (phosphonoformic acid, 4,22) is an anti-viral which acts by binding to the pyrophosphate-combining site of DNA polymerase, but only on the virus-specified enzyme. It is usually applied topically to the lesions of herpes (Larsson and Oberg, 1981). Sodium phosphonoacetate acts similarly (Overby, Duff and Mao, 1977). 

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