Formation of carbon-halogen bonds

Halogenated organic compounds are important end products of organic syntheses in both academic research and industry, where they find use as solvents, plastics, drugs, dyestuffs, pesticides, and weedicides. Their role as intermediates is at least equally vital they are stepping stones in very numerous procedures for the junction of C—N, C—O, and C—C bonds and for formation of C—O, C=C, and C=C bonds. 

In the following pages particular attention is paid to the bromination procedures that are most easily carried out on the laboratory scale, but most of the processes of fluorination, chlorination, iodination, and of formation of thiocyanates customarily used in the laboratory are also included (for detailed accounts of the preparation of organic fluorine and chlorine derivatives see reference, la, li and for bromine and iodine compounds see reference). The material is classified according to the type of reaction and the class of compound produced. 

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S. Torii, T. Inokuchi, Addition Reactions with Formation of Carbon-Halogen Bonds, in Comprehensive Organic Synthesis (B. M. Trost, I. Fleming, Eds.), Vol. 7, 527, Pergamon Press, Oxford, 1991. 

Formation of carbon-halogen bonds (Cl, Br, I) VI. HALOGEN-HALOGEN REAGENTS... 

Me3SiX with X = Cl, Br, I are relatively new reagents that are very reactive and selective for the formation of carbon-halogen bond. 

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