Food obesity impairment

Globally, undernutrition is widespread, leading to impaired growth, defective immune systems, and reduced work capacity. By contrast, in developed countries, there is often excessive food consumption (especially of fat), leading to obesity and to the development of cardiovascular disease and some forms of cancer. Deficiencies of vitamin A, iron, and iodine pose major health concerns in many countries, and deficiencies of other vitamins and minerals are a major cause of iU health. In developed countries, nutrient deficiency is rare, though there are vulnerable sections of the population at risk. Intakes of minerals and vitamins that are adequate to prevent deficiency may be inadequate to promote optimum health and longevity. 

Homozygous VLDL receptor knockout mice are resistant to both genetic and diet-induced obesity caused by a decreased peripheral and whole-body uptake of NEFA with no alterations in eifher food intake or fat absorption [112]. The reduction in adipocyte TAG storage as shown by a decreased average fat cell size in VLDL receptor-deficient rodents implies an impaired FA delivery to adipose tissue in the absence of this lipoprotein receptor. Analogously, hepatic overexpression of hu-... 

Excessive food intake does not always lead to obesity nor does moderate food intake guarantee leanness. Indeed, the high energetic efficiency of several obese rodents indicate that obesity can in part result from impaired energy expenditure. Recently, research has focused on the relationship between thermogenic activity in brown adipose tissue (BAT) and energy balance. 

It is necessary for nutritionists to obtain accurate estimates of the caloric values of various diets in order to help people avoid the consumption of too I little or too much food energy. For example, a chronic dietary deficit of calories may result in the wasting of muscles and other body tissues and a temporary or permanent impairment of certain functions. On the other hand, long-term dietary excesses of food energy may lead to obesity which is believed to increase the risk of diabetes, heart disease, and high blood pressure. 

---