Folic acid peptides

Folic acid and its derivatives (mostly the tri-and heptaglutamyl peptides) are widespread in nature. It is a specific growth ctor for certain micro-organisms, but in animals the intestinal bacteria provide the small quantities needed for growth. The coenzyme forms are actually... 

As shown in Figure 10.1, folic acid consists of a pteridine linked at C-9 to p-aminobenzoic acid, forming pteroic acid. The carboxyl group of the p-aminobenzoic acid moiety is linked by a peptide bond to the amino group of glutamate, forming pteroyl monoglutamate. 

There are five chapters contained in this book. Each one is written by a recognized expert in the field. The areas of focus are Ion-Selective Electrodes, the Somatomedins, Synthetic Peptide Substrate Assays for Hemostasis Testing, Bile Acids, and Folic Acid. 

Folic acid cofactors (1) are derived from tetrahydropteroic acid linked to the a-amino function of poly-y-glutamyl peptides of varying chain length (n = 1-8). The absolute configuration at C-6 for tetrahydrofolate (H4-folate) which should also include the pteroyl polyglutamates, has been defined as S) by X-ray studies on... 

Apart from amino acids, peptides and proteins, many other metal-binding substances play essential roles in all living cells. Firstly, there are the pteridines (including folic acid) and purines, whose stability constants have been determined (Albert, 1953 Albert and Serjeant, 1960). Riboflavine is most avid in the partly reduced state (Hemmerich, Veeger and Wood, 1965). Spermine 11 A), and the diamines spermidine 11.5) and putrescine 11.6) also compete. 

Folic acid (pteroylglutamic acid) is a pteridine derivative, especially plentiful in liver, yeast and green plants. Chemically, it consists of 3 moieties 2-amino-4-hydroxypteridine, p-aminobenzoic acid and one or more glutamic acid residues, linked by peptide bonds via their y-carboxyl groups. Folic acid is a growth factor for some bacteria. 

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