Folex - Methotrexate

Methotrexate is used to treat severe lymphatic leukemia, choriocarcinoma, non-Hodgkin s lymphoma, bone carcinoma, as well as head, neck, breast, and lung tumors. Synonyms of this drug are farmitrexate, ledertrexate, ematexate, maxtrex, folex, mexate, and others. 

Methotrexate (Folex, Rheumatrex) is an antimetabolite used frequently in the treatment of cancer (see Chapter 36). There is considerable evidence that this drug is also one of the most effective DMARDs.15 76 Methotrexate has been shown to slow the effects of rheumatoid arthritis as evidenced by decreased synovitis, decreased bone erosion, and less narrowing of the joint space.37 The therapeutic effects of methotrexate have also been reported to be equal to, or better than, other DMARDs such as oral gold or azathioprine, and methotrexate may offer an advantage in terms of a rapid onset.68,90 Hence, methotrexate s popularity as a DMARD has increased during the past few years, and this drug is often the first DMARD used to treat rheumatoid arthritis in both adults and children.76... 

Methotrexate Folex, Rheumatrex - Rheumatoid arthritis, psoriasis... 

Methotrexate 2.5-5 mg/d orally (Rheumatrex) 10 mg intrathecally (Folex) once or twice weekly Mucositis, diarrhea, bone marrow depression with leukopenia and thrombocytopenia... 

Antimetabolites selectively compete for intermediary metabolites critical to immime cell function, exerting a cytotoxic effect. Methotrexate (Folex ), which inhibits folic acid, is the most widely recognized and used drug in this class. Other antimetabolites that may be used in treating uveitis include azathioprine (Imuran ) and mycophe-nolate mofetil (CellCept ), both of which interfere with purine metabolism. 

Risk of methotrexate (Folex) toxicity because of decreased ability to excrete methotrexate... 

Two other dmgs affected by penicilhn are methotrexate (Folex) and probenecid (Benemid). There is a decrease in the body s abihty to clear methotrexate when penicilhn is present. There can be a build up of methotrexate resulting in toxicity. 

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