Alpha-folate receptor

Sinn, P. L., Hickey, M. A., Staber, P. D., Dylla, D. E., Jeffers, S. A., Davidson, B. L., Sanders, D. A. and McCray, P. B., Jr. (2003). Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithe-lia from the apical surface independently of folate receptor alpha. J. Virol. 77, 5902-5910. 

B. A. Kamen and A. K. Smith, A review of folate receptor alpha cyding and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro. Adv. Drug Deliv. Rev., 56, 1085-1097 (2004). 

Kotsopoulos, J., Hecht, J.L., Marotti, J.D., Kelemen, L.E., and Tworoger, S.S., 2010. Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors. International Journal of Cancer. 126 2191-2198. 

Inborn errors of folate metabolism also shed light on the role of folates and products of folate metabolism in neurological function. Disorders that result in decreased levels of 5-CH3-THF in the central nervous system are frequently associated with development of seizures e.g. MTHFR deficiency, DHFR deficiency, MTHFDl deficiency, and autoimmune or genetic cases of cerebral folate deficiency due to malfunction of folate receptor alpha). Adult onset cases of MTHFR deficiency have in some cases been associated with psychosis. 

Ntziachristos, V. 2011. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting First in-human resnlts. Nat Med, 17, 1315-9. 

M. Bagnoli, A. Tomassetti, M. Figini, S. Flati, V. Dolo, S. Canevari, and S. Miotti. Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression. Oncogene 19 4754-4763 (2000). 

Miotti, S., Bagnoli, M., Tomassetti, A., Colnaghi, M. I., and Canevari, S. (2000). Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1. /. Cell Sci. 113(Pt 2), 349-357. 

Theti, D. S. and Jackman, A. L. 2004. The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clinical Cancer Research 10 1080-1089. 

Steinfeld, R., Grapp, M., Kraetzner, R., Dreha-Kulaczewski, S., Helms, G., Dechert, P., Wevers, R., Grosso, S., and Gartner J., 2009. FDolate receptor alpha defect causes cerebral folate transport deficiency a treatable neuro-degenerative disorder associated with disturbed myelin metabolism. American Journal of Human Genetics. 85 354-363. 

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