Fluvastatin adverse effects

Colchicine is cleared by a different CYP450 isozyme than fluvastatin and pravastatin are, but another possible mechanism is synergistic myotoxicity, since colchicine causes myopathy by disrupting tubular function with subsequent vacuolization. Patients taking colchicine should be informed about possible muscular and gastrointestinal adverse effects and advised to stop. 

PROTEASE INHIBITORS ATORVASTATIN t efficacy and t risk of adverse effects of atorvastatin Inhibition of CYP3A4-mediated metabolism of atorvastatin Use with caution. Monitor for atorvastatin toxicity, and monitor CK. Inform patients and 1 dose if necessary or start with 10 mg once daily. Use the lowest dose possible to attain the target low-density lipoprotein 1. Alternatives are pravastatin and fluvastatin... 

It has been suggested that the pharmacokinetics of fluvastatin, including extensive biliary excretion and absence of circulating active metabolites, might be associated with a low incidence of systemic adverse effects compared with other statins. In over 1800 patients treated for an average of 61 weeks, fluvastatin was safe and tolerable (SEDA-19, 408). Pooled data from clinical trials have shown that gastrointestinal symptoms occurred in 14% of fluvastatin recipients compared with 9% taking placebo other complaints occurred... 

C. Toxicity Adverse effects include bloating, constipation, and an unpleasant gritty taste. Absorption of vitamins (eg, vitamin K, dietary folates) and drugs (.eg, digitalis, thiazides, warfarin, pravastatin, fluvastatin) may be impaired by the resins. 

In a randomised, crossover study 15 patients were given fluvastatin 20 mg and gemfibrozil 600 mg twice daily. The pharmacokinetics of both gemfibrozil and fluvastatin were unchanged by concurrent use and no significant adverse effects were noted."... 

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