Fluticasone propionate cream

Fluticasone propionate cream 0.05% contains fluticasone propionate [(6(alpha),ll(beta),16(alpha),17(alpha))-6,9,-difluoro-11 -hydroxy- 16-methyl-3-oxo-17-(l -oxopro-poxy)androsta-l,4-diene-17-carbothioic acid, S-fluoromethyl ester], a synthetic fluorinated corticosteroid for topical dermatologic use. The topical corticosteroids constitute a 

Melt cetostearyl alcohol and cetomacrogol 1000 in a fat-melting vessel at 70°C. Add liquid paraffin and isopropyl myristate and mix well. Hold the temperature between 60° and 70°C. 

Transfer the fat phase of step 1 through a stainless steel filter to the manufacturing vessel while stirring at a temperature of 60°-70°C. Mix and homogenize for 10 minutes under vacuum at 0.5 bar. Cool the mixture to 40° 45°C. 

Disperse fluticasone propionate in propylene glycol at a temperature of 40° 15oC. 

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Fluticasone propionate Cutivate cream 0.05%, oint 0.005% Intermediate... 

Fluticasone propionate is administered by nasal spray in the prophylaxis and treatment of allergic rhinitis, but is applied topically in the treatment of various skin disorders (as creams and ointments). 

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