Flurazepam Alcohol

Diazepam is used for the control of anxiety and tension, the relief of muscle spasms, and the management of acute agitation during alcohol withdrawal, but it itself may be habit-forming. Chlordiazepoxide has similar uses and its synthesis is somewhat analogous to diazepam. Flurazepam is a hypnotic, useful for insomnia treatment. It is reported to provide 7-8 hr of restful sleep. 

Benzodiazepines are also used for several other conditions that are related to, but not actually termed, anxiety. For example, benzodiazepines are commonly given as soporific or hypnotic drugs (drugs that help people sleep). One of the benzodiazepines, flurazepam, is the most frequently prescribed hypnotic drug in the United States. Benzodiazepines also are administered as muscle relaxants, and can even reduce the occurrence of seizures or convulsions. Another common use of benzodiazepines is in alcohol withdrawal. Someone who is trying to stop drinking alcohol is usually given a heavy dose of... 

This fivefold clinical activity is possessed, to a greater or lesser extent, by all benzodiazepines in current clinical use. The properties of benzodiazepines make them ideally useful for managing anxiety (e.g. diazepam, chlordiazepoxide, lorazepam) insomnia (e.g. diazepam, temazepam, nitrazepam, loprazolam, flurazepam, lormetazepam) epilepsy (e.g. clobazam, diazepam, lorazepam) sports injuries where muscle relaxation is required (e.g. diazepam) and as premedications prior to surgery (e.g. midazolam, lorazepam). The benzodiazepines have a number of other uses, including management of alcohol withdrawal syndrome (chlordiazepoxide, diazepam) and restless legs (clonazepam). Short... 

Clinically important, potentially hazardous interactions with alcohol, anticholinergics, barbiturates, benzodiazepines, butabarbital, chloral hydrate, chlordiazepoxide, chlorpromazine, clonazepam, clorazepate, diazepam, ethchlorvynol, fluphenazine, flurazepam, hypnotics, lorazepam, MAO inhibitors, mephobarbital, mesoridazine, midazolam, narcotics, oxazepam, pentobarbital, phenobarbital, phenothiazines, phenylbutazone, primidone, prochlorperazine, promethazine, quazepam, secobarbital, sedatives, temazepam, thioridazine, tranquilizers, trifluoperazine, zolpidem... 

As well as the opioids cocaine and cannabis, polytoxicomane drug abusers also consume bromazepam, diazepam and flunitrazepam in high doses, and fatalities among drug abusers and substitution patients can often be blamed on the consumption of these substances, often in combination with alcohol [48]. Patients who suffer low-dose dependence, in addition to consuming the three above-named substances, also consume therapeutic amounts of dipotassium clorazepate, flurazepam, lorezepam, nitrazepam or oxazepam, sometimes also in combination with amphetamines or antihistamines. 

It is very difficult to assess and compare the results of the very many studies of this interaction because of the differences between the tests, their duration, the dosages of the benzodiazepines and alcohol, whether given chronically or acutely, and a number of other variables. However, the overall picture seems to be that benzodiazepines and related drugs including diazepam, " alprazolam,bromazepam, brotizolam, chlo-rdiazepoxide, " clobazam, dipotassium clorazepate, flunitrazepam, flurazepam, loprazolam, " lorazepam, lormetazepam, medazepam, midazolam, nitrazepam, " " oxazepam, temazepam, " triazolam, and zopiclone enhance the effects of alcohol i.e. cause increased drowsiness, impaired performance and driving skills. 

Some of the benzodiazepines and related drugs that are used primarily to aid sleep, such as flunitrazepam, flurazepam, "" "" nitrazepam, " and temazepam, when taken the night before alcohol or in the evening with alcohol, can still interact with alcohol the next morning. However, midazolam,- loprazolam, lormetazepam, triazolam, Zolpidem, and zopiclone have been reported not to do so. The sedative effects of midazolam alone, and midazolam with fenta-nyl have been shown to have dissipated within 4 hours, and to not be affected by alcohol after this time. However, some patients may metabolise midazolam more slowly and so an interaction could still be possible, especially in older patients or those receiving additional drugs. ... 

Mendelson WB, Goodwin DW, Hill SY, Reichman JD. The morning after residual EEG effects of triazolam and flurazepam, alone and in combination with alcohol. Curr TherRes Clin Exp (1976) 19, 155-63. 

The disposition of flurazepam (IV) was examined in a dog and man. The compound was metabolized by successive N-dealkylation to yield, ultimately, the alkylamine, whi was excreted in the urine. Man oxidatively deaminated the alkylamine to a conjugate of the homologous alcohol, whereas the dog formed the corresponding carboxylic acid, both presumably via an aldehyde intermediate. A metabolite also found in the urine of both species was the fluorinated analogue of oxazepam, although this metabolite is probably formed by a pathway in which N-dealkylation precedes 3-hydroxylation, since the 3-hydroxy derivative of flurazepam was not detected in urine. 

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