5-Fluorouracil anabolism

Bading, J.R., Too, P.B., Fissekis, J.D., Alaud-din, M.M., D Argenio, D.Z., and Conti, P.S. Kinetic modeling of 5-fluorouracil anabolism in colorectal adenocarcinoma a positron emission tomography study in rats. Cancer Res.,... 

Substantial attention has been devoted to the metabolism of 5-fluorouracil and related compounds. For example, F NMR was used successfully both in cell extracts and in whole mycelia to elucidate anabolic reactions involving pyrimidine nucleotides and degradation to a-fluoro-p-alanine in the fungus Nectria haematococca (Parisot et al. 1989,1991). 

Fluorouracil is anabolized to its 2 -deoxyribosc mo phosphate, a potent inhibitor of thymidylate synthetiiic also is converted into fluorouridine triphosphate, whiilii incorporated into RNA and DNA." There is cell Ou phase-specificity for the S phase. 

Fluorouracil is a pyrimidine antimetabolite. The metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to chymidylic acid. In this manner, fluorouracil interferes with the synthesis of DNA and to a lesser extent inhibits the formation of RNA. It is indicated in colon, rectum, breast, gastric, and pancreatic carcinoma (injection) multiple actinic or solar keratoses, and superficial basal-cell carcinoma (topical). 

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