4-fluorophenyl 2- phenyl

A few functional dihalides have been prepared. Some of these monomers are tabulated in Table 6.2. The monomers could be nitrated and then reduced to amine-functionalized monomers (Scheme 6.26).203 This approach was used to nitrate DCDPS or bis-4-fluorophenyl phenyl phosphine oxide.204 These monomers were used to copolymerize with some other activated dihalides as the comonomers. 

BFPPO. See Bis(4-fluorophenyl)phenyl phosphine oxide (BFPPO)... 

Bis(4-fluorobenzoyl)phenol, 349 Bis(4-fluorophenyl)phenyl phosphine oxide (BFPPO), 345. See also BFPPO monomer Bis(haloaryl) sulfones, 364 Bishaloimides, 346... 

As shown in Scheme 7, the polymerization of bis(4-fluorophenyl) phenyl-phosphine oxide (BFPO) with bisphenols [XIII] was carried out, and thermal properties of the obtained polyethers [XIV-A (ffinh = 0.63 dl/g) and XIV-B i)inh = 0.48 dl/g)] were studied by DSC and TG (12). In this study, 2,2-bis(4-hydroxyphenyl) propane and 4,4 -dihydroxybiphenyl were used as compounds XIII s. 

When l,l,3,3-tetramethyl-2,l,3-thiadisilolane is used as sulfur reagent, another type of reaction takes place. Two molecules of the fluorine-containing compound become linked via a sulfur bridge with elimination of a fluorine atom from each.31 Thus, (4-fluorophenyl)phenyl-methanone reacts with l,l,3,3-tetramethyl-2,l, 3-thiadisilolane in TV. A -dimethylacetamide (with catalytic amounts of CsF, 12 h at 120 C, under N2) to give bis(4-bcnzoylphenyl) sulfide in 81 % yield.31... 

Fluorophenyl Phenyl Tellurium Dichlorideh 7.7 g (52 mmol) of 4-fluoroaniline hydrochloride are diazotized in 25 ml of 15% hydrochloric acid at 0°. A solution of 12.3 g (30 mmol) of diphenyl ditellurium in 250 ml of acetone and 50 ml of acetonitrile is placed in a 1 / flask and the solution is heated to 50°. The iee-cold diazonium salt solution is rapidly added to the vigorously stirred ditellurium solution and then a solution of 10.3 g (60 mmol) of eopper(II) chloride dihydrate in 15 m/ of water is added dropwise over 3 min. When the vigorous evolution of nitrogen has ceased, a large part of the solvent is distilled from the mixture and 150 ml of water together with 100 ml of benzene are added. The stirred mixture is heated under reflux for 20 min, allowed to cool, the benzene layer is separated, dried with anhydrous calcium chloride, and passed through a... 

Intermediates benzene to ethyl phenyl ketone to ethyl m nitrophenyl ketone to m aminophenyl ethyl ketone to ethyl m fluorophenyl ketone Reagents propanoyl chloride AICI3 HNO3 H2SO4 Fe HCl then HO NaN02 H2O HCl then HBF4 then heat... 

In step 2, phenol or trifluorethanol is used, but phenol is preferred. Examples of (21) prepared by this method iaclude R = methyl [138815-47-17, ethyl [146525-87-3], phenyl [138815-48-2], and 4-fluorophenyl [146525-88-4], Another preparation is shown ia equation 9, where R OH is phenol or trifluoethanol. 

Methoxytetrahydrothiopyranyl S,S-Dioxide, 55 1 -[(2-Chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl, 55 1 -(2-Fluorophenyl)-4-methoxypiperidin-4-yl, 56... 

Chemical Name 1 -[Bis(4-fluorophenyl)methyl] -4(3-phenyl-2-propenyl)piperazine Common Name —... 

Chemical Name 8-[4,4-bis(p-fluorophenyl)butyl] -l-phenyl-1,3,8-triazaspiro[4.5] decan-4-one... 

A mixture of 7.3 parts l-chloro-4,4-di-(4-fluorophenyl)-butane, 5.1 parts l-phenyl-4-oxo-l,3,8-triaza-spiro(4,5)-decane, 4 parts sodium carbonate, a few crystals of potassium iodide in 200 parts 4-methyl-2-pentanone is stirred and refluxed for 60 hours. After cooling the reaction mixture is treated with water. The organic layer is separated, dried, filtered and evaporated. The solid residue is recrystallized from 80 parts 4-methyl-2-pentanone, yielding l-phenyl-4-oxo-8-[4,4-di-(4-fluorophenyl)-] butyl-1,3,8-triaza-spiro(4,5)decane, melting point 187.5° to 190°C. 

Chloro-7-(2-fluorophenyl)-5/f-dibenz[c,e]azepine (54) has been prepared in a similar manner from 2-[2-(bromomethyl)phenyl)-5-chloro-2 -fluorodiphenyl ketone (53, X = Br),93 but can be obtained in a superior yield (85%) as the methanesulfonate salt by cleavage of the [(dimethylamino)methyl] derivative 53 (X = NMe2) with cyanogen bromide followed by treatment with ethanolic ammonia.94... 

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