Fluorometholone formulations

Suspension. If the drug is not sufficiently soluble, it can be formulated as a suspension. A suspension may also be desired to improve stability, bioavailability, or efficacy. The major topical ophthalmic suspensions are the steroid anti-inflammatory agents prednisolone acetate, dexamethasone, fluorometholone, and rimex-olone. Water-soluble salts of prednisolone phosphate and dexamethasone phosphate are available however, they have a lower steroid potency and are poorly absorbed. 

Unlike prednisolone and dexamethasone, which are structurally related to cortisol, fluorometholone is a fluo-rinated structural analogue of progesterone. Formulated both as an alcohol and acetate derivative, fluorometholone has proven to be an effective agent in external ocular inflammations, with relatively low potential for elevating lOP. 

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