Benzaldehyde 0-fluoro

Chloro 4 fluoro benzaldehyde silafluofen p.Chloro fluoro benzene flusilazole... 

This unsaturated amide is known as cinflumide and is a muscle relaxant. Disconnection of the amide gives an acid chloride that we can make by FGI from the acid. You should then spot the a,P-unsaturated carbonyl disconnection, a masked 1,3-diO disconnection, back to m-fluoro-benzaldehyde. 

Salicylaldehydes react with hydrazine to give IH-indazolesand indazoles can also be formed from the reaction of orf/to-fluoro-benzaldehydes with hydrazine. " Rather similar ring closnres of N-aryl-N -(ortho-bromobenzyl)-hydrazines require palladium catalysis. ... 

At this time, an even more streamlined approached to oxazinone 1 was investigated. A modified Strecker reaction between 4-fluoro-benzaldehyde and A-benzylethanolamine (NBEA) afforded aminonitrile 16, which was extracted into IPAC (Scheme 7). The subsequent Pinner reaction was effected by addition of HCl (g) to this solution. Imidate hydrochloride 17 HC1 was formed and residual water caused spontaneous hydrolysis to lactone hydrochloride l-HCI. This slurry could be filtered to afford the crystalline lactone hydrochloride (containing ca. 15 wt% NH4CI) or alternatively and preferably it could be treated with aqueous KHCO3 to freebase the amine. The resulting IPAC stream fed directly into the crystallization-induced resolution procedure that had been established. 

The reaction of 2/f-chromene-3-carboxaldehyde (168, R = H) with p-fluoro-benzaldehyde in the presence of an NHC and base was expected to produce a lactone, via homoenolate chemistry of (168). Instead, 3-methyl-2//-chromene-2-one (169, R = H, i.e. 3-methylcoumarin) was formed. The unexpected result was obtained again with the benzaldehyde omitted. Using a 2-methyl substrate (168, R = Me) results in a similar product, that is, 3-et/iy/coumarin (169, R=Me). ... 

Acetals of 3-bromo-4-fluoro benzaldehydes have been successfully subjected to the Ullmann reaction with several phenolates and anilines, leaving the fluorine untouched, producing the following intermediates ... 

In an expeditious multicomponent condensation, (2-cyanomethyl)pyridine, 2-fluoro-benzaldehyde, and cyclohexylisocyanide react in BuOH solution in the presence of DBU at 100 °C (24 h) giving rise to a product A in 69% yield. 

Fig. 9 The molecules of 5-(aryltelluro)-6-(phenylselenyl)acenaphthenes (a), 2-fluoro-benzaldehydes (b), and P,P-3-ferrocenophanes (c) exhibiting through-space indirect spin-spin coupling.

Exploratory Study of Terpenyl Alcohols for MBH Reaction of Fluoro-benzaldehydes... 

Multi-step syntheses of a radiopharmaceutical involving an aromatic nucleophilic radiofluorination An example of a multi-step radiosynthetic pathway is the no-carrier-added synthesis of 6-[ F]fluoro-L-DOPA (Scheme 45). The first step involves the preparation of 4,5-dimethoxy-2-[ F]fluorobenzaldehyde from the corresponding nitro-substituted benzaldehyde. The following steps involve its condensation with an asymmetric chiral inductor [206] followed by L-selectride reduction of the... 

In related studies, it has been shown that a-fluorobenzylphosphonates ArCHFPO(OEt)2 (38) will undergo Wadsworth-Emmons-type olefination reactions with aldehydes and ketones [57]. 39 was prepared from benzaldehydes and HP(0) (OEt)2, which was fluorinated using diethylaminosulfur tiifluoride for example, diethyl [(3,5-dimethylphenyl)(fluoro)methyl]phosphonate (38) was formed in 91%. An 82% yield of Me 2-[(fluoro)(4-fluorophenyl)methylene]butanoate (1 1 E Z) (40) was obtained from 38 and methyl 2-oxobutanoate (Scheme 13). 

Thiol anions normally add reversibly to uracil derivatives <1991T4361>, although stable adducts can be isolated when the intermediate enolate is trapped with an added electrophile <2006JHC1095>. Thus, the addition of lithium phenylthiolate to 5-fluoro-l,3-dimethyluracil 457 in the presence of benzaldehyde gave a 46% yield of the adduct 458 as a mixture of only two diastereomers <2006JHC1095>. 

Benzaldehyde, 4-ethoxy-3-methoxy-, 56, 44 Benzaldehyde, 4-ethoxy-3-methoxy-, ethylene acetal, 56, 44 Benzaldehyde, 4-isopropyl-, 55,10 Benz[e ] anthracene, 58, 15, 16 BENZENAMINE, 4-bromo-Ar, V-dimcthyl-3-(tnfluoromethyl)-, 55, 20 Benzene, bromo-, 55,51 Benzene, 1 bromo-4-chloro-,55, 51 Benzene, 4-bromo-l, 2-dimethyl, 55, 51 Benzene, l-bromo-4-fluoro-, 55, 51 Benzene, 1 -bromo-4-methoxy-, 55,51 Benzene, l-bromo-3-methyl-, 55, 51 Benzene, 4-(cr/-buty 1-1-ethyl, 55, 10 Benzene, chemical hazard warning, 58, 168 Benzene, chloro-,56, 86 Benzene, l-ethyl-4-isopropyl-, 55, 10... 

This method of preparation of a halobenzaldehyde is of wide application and has been used for the preparation of the following substituted benzaldehydes 2-bromo-5-methyl-,4 2,3-dichloro-and 2,4-dichloro-,5 2-chloro-4-methyl-,-iodo-, />-fluoro-, 2-iodo-4-methyl-, and 6-iodo-3-methyl-.9... 

On reaction of 2-(3-fluoro-4-methylphenyl)-2//-naphtho[l,2-c ]tria-zole (225) with the Schiff s base from benzaldehyde and p-chloroaniline with potassium hydroxide in DMF, it has been reported68 that, not the expected stilbene, but rather the dihydroquinoline 226 is formed. It was... 

Sarel et al. (112,115) found also that the pilosine originally isolated from P. jaborandi was a 1 1 molecular compound composed of (-l-)-pilosine and (-t-)-isopilosine. The mass spectra of 50,51, and 52 have been studied, and a detailed investigation of the aldol condensation between pilosinine and benzaldehyde and its 2- and 4-fluoro derivatives has been described (112). 

Fluoro-2-phenylacctonitriles are obtained in high yield with diethylaminosulfur trifluoride (DAST) from the corresponding cyanohydrin trimethylsilyi ethers, which were in turn obtained from substituted benzaldehydes and cyanotrimethylsilane. For example, 2-fluoro-2-phenyl-acetonitrile (5) is obtained from the trimethylsilyi ether 4. ... 

On the other hand, in the reaction of trifluoroiodomethane and tris(diethylamino)phos-phane other products are formed, namely bis(diethylamino)(trifluoromethyl)phosphanc [(EtjNlaPCFj] and the salt (Et2N)4P l The salt 16 is stable up to its melting point. The high positive charge on the phosphorus atom in this compound promotes the reaction with the fluoride ion (arising from CsF, TASF, etc.). The fluoro-A -phosphane 17 is formed as an intermediate in this reaction. It reacts, for example, with benzaldehyde to form the alcohol 18. ... 

---