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Fluorine substitution effect methods

The natural stable isotope of fluorine, fluorine-19 (19F), with a spin of one-half and a chemical shift range of around 300 ppm, is a sensitive and useful probe in nuclear magnetic resonance (NMR) studies. Fluorine substitution may be a very effective method for studying the fate of bioactive molecules. Since there are few natural fluorinated materials to create background signals, the analyses are freed from the complications often associated with proton NMR spectroscopy (65). An artificially prepared useful short-lived isotope, fluorine-18 (18F), decays by positron emission. Positron emission tomography (PET) is an especially useful non-invasive... [Pg.11]

AUcorta et aV studied the effect of fluorine substitution on a series of HB systems with the aid of ab initio methods. The atomic properties of a series of charge transfer and HB complexes have been compared. [Pg.407]

There are a certain number of options to control and reduce dental caries, the biggest problem in tooth care. The use of fluoride salts is one of the most effective methods to prevent or slow down demineralization that causes tooth decay [16,17]. The action of fluoride can be explained by its antimicrobial action, its interaction with enamel to form a fluorinated hydroxyapatite compound (hydroxyfluorapa-tite or fluorapatite Ca5(P04)3F) by substitution of an hydroxyl ion in hydroxyapatite Ca5(P04)3(0H), which is more resistant to add than enamel on its own, and its repairing effect by formation of calcium and phosphate, which ranineralize the tiny lesions in which caries begin. [Pg.129]

Because the high attenuation of PMMA is caused by overtones of the C-H vibrational absorption, the most effective method for obtaining a low-loss POF is to substitute all the hydrogen atoms with heavier atoms such as fluorine, which helps to avoid the water absorption problem mentioned above. The replacement of hydrogen with fluorine also improves the thermal stability, chemical resistance, and electrical properties of POFs. The size of the fluorine atom allows the formation of a uniform and continuous sheath around the carbon-carbon bonds and protects them from attack, thus imparting heightened chemical resistance and stability to the molecule. [Pg.61]

The double-isotopic fractionation method was employed in this study. This procedure consists of the use of deuterium substitution to selectively slow down the rate of one step in a reaction and observing the changes in a second kinetic isotope effect. In this study flie aim is to obtain information from the secondary D KIE at C4 and the fluorine isotope effects, respectively. For that reason, substrates on which the deuterium has been placed at C3 to slow down the step in which the C3-H bond is being broken, have been employed. Then, the extra labels were deuterium at C4 (compound 4) and labeled fluorine (compound 6) (atoms colored red in Fig. 37.1). Compounds 3 and 4 were used to determine the effect of the deuterium at C3 on the secondary D KIE values at C4 (k lk ) (Fig. 37.1). Similarly, compounds 5 and 6 were used to study the influence of the deuterium label at C3 on the leaving group F KIEs... [Pg.244]

Diels-Alder reactions, 4, 842 flash vapour phase pyrolysis, 4, 846 reactions with 6-dimethylaminofuKenov, 4, 844 reactions with JV,n-diphenylnitrone, 4, 841 reactions with mesitonitrile oxide, 4, 841 structure, 4, 715, 725 synthesis, 4, 725, 767-769, 930 theoretical methods, 4, 3 tricarbonyl iron complexes, 4, 847 dipole moments, 4, 716 n-directing effect, 4, 44 2,5-disubstituted synthesis, 4, 116-117 from l,3-dithiolylium-4-olates, 6, 826 electrocyclization, 4, 748-750 electron bombardment, 4, 739 electronic deformation, 4, 722-723 electronic structure, 4, 715 electrophilic substitution, 4, 43, 44, 717-719, 751 directing effects, 4, 752-753 fluorescence spectra, 4, 735-736 fluorinated derivatives, 4, 679 H NMR, 4, 731 Friedel-Crafts acylation, 4, 777 with fused six-membered heterocyclic rings, 4, 973-1036 fused small rings structure, 4, 720-721 gas phase UV spectrum, 4, 734 H NMR, 4, 7, 728-731, 939 solvent effects, 4, 730 substituent constants, 4, 731 halo... [Pg.894]

In a series of comparative studies Dolle et al. examined the nucleophilic aromatic substitution of a number of nitropyridine derivatives [104—106], The results, as summarized in Scheme 13.14, show that under microwave-enhanced conditions the 2-N02 and 2-+NMe3 groups led to excellent fluorine incorporation whilst the 2-iodo compound was virtually unreactive. Under thermal conditions no fluorination was observed for the 2-chloro and 2-bromo compounds. In a separate study Banks et al. [107] again observed the beneficial effects of nitro and trimethylamino substitution (Scheme 13.15). The authors also developed a novel microwave-enhanced method of producing [18F]-fluoromethane [108]. [Pg.456]

As mentioned in the introduction, partially fluorinated compounds are highly useful, however methods for their synthesis are strictly limited in many cases. For example, nucleophilic substitution occurs with difficulty at the position a to a trifluoromethyl group due to its strong electron-withdrawing effect, although sulfur and selenium nucleophiles undergo such a substitution rather efficiently (Scheme 6.1). [Pg.25]


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See also in sourсe #XX -- [ Pg.331 ]

See also in sourсe #XX -- [ Pg.331 ]




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Fluorination methods

Fluorine substitution

Fluorine, effect

Fluorine-substituted

Substitution fluorination

Substitution method

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