Effects of Fluorination on Bond Energies and Reactivity

This strengthening of C—F, C—H, and C—O bonds, through a- or //-fluorination, gives fluoroalkyl compounds a significantly greater chemical, thermal, and enzymatic 

GENERAL REMARKS ON STRUCTURAL, PHYSICAL, AND CHEMICAL PROPERTIES 

The C—bond strength renders the aliphatic fluorides much less reactive than the corresponding chlorides in S l or Sn2 reactions (from 10 to 10 ). In fluoroalkenes, the C—bond is also strong the more fluorine atoms there are, the stronger the n double bond is. In general, the reactivity of these double bonds decreases with electrophiles while it increases with nucleophiles. 

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