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Fluorinated carbohydrates, biological activity

Synthesis and Biological Activities of Compounds Containing Fluorinated Carbohydrates. 186... [Pg.91]

The selective introduction of fluorine is of continuing interest not only because of the synthetic challenge but also because of the possibility of a dramatic change in biological activity. The fluoride-ion displacement of carbohydrate trifluoromethanesulfonates using tris(dimethylamino)sulfonium... [Pg.2]

Building blocks derived from microbial transformations are usually employed as the key units of fluorinated analogs of appropriate natural products or synthetic biologically active materials [42-45]. Among such useful compounds, trifluoromethylated carbohydrates constitute one of the most interesting fields for intensive study. Novel and efficient routes to access a variety of chiral... [Pg.107]

A. B. Foster Synthesis and biological activity of fluorinated carbohydrates... [Pg.52]

Fluorinated carbohydrates have recently received much attention because of their importance in the study of the enzyme-carbohydrate interactions and their interesting biological activity [56], Hara et al. [57] achieved the deoxyfluorination of primary and anomeric hydroxyl groups of a series of protected carbohydrates, for example 65 into 66 (70%) (Scheme 12.31, a representative example) and 67 into 68 (90%) (Scheme 12.32, a representative example), with good yields, by use of N,N-diethyl-a,a-difluoro-(m.-methylbenzyl)amme (DFMBA), which has previously proved to be a selective reagent for the synthesis of fluorinated alcohols and carboxylic acids [58], Chemoselective deoxyfluorination at the anomeric position... [Pg.596]

As part of an issue of Carbohydrate Research devoted to reviewing the whole area of fluorinated sugars, Pankiewicz has discussed nucleosides fluorinated in the sugar moiety, covering both synthesis and biological activity. Another review has also covered recent strategies for the synthesis of fluoronucleosides, with some consideration of structure-activity relationships. ... [Pg.255]


See other pages where Fluorinated carbohydrates, biological activity is mentioned: [Pg.196]    [Pg.281]    [Pg.13]    [Pg.201]    [Pg.115]    [Pg.242]    [Pg.106]    [Pg.60]    [Pg.60]    [Pg.17]    [Pg.17]   
See also in sourсe #XX -- [ Pg.201 , Pg.204 ]




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