Fluorinated sugars

Certain esters of dibasic carboxylic acids Loss of (C3H9SiF) for fluorinated sugars... 

Excellent reviews on fluorinated sugars (and related fields) have been published. " In every Section in the present article, work reported in 1978-1988 is emphasized, although important earlier studies are also included, and this article is fundamentally a succession to that by Penglis in this Series. 

NMR Studies of Fluorinated Sugars Binding to the Glucose and Galactose Receptor... 

Figure 3. Use of 2-deoxyribose-5-phosphate aldolase in the synthesis of fluorinated sugars, (a) Normal reaction, (b) synthesis of l-fluoro-4-hydroxy-5-methyl-hexan-2-one, (c) synthesis of 2,5-dideoxy-5-fluororibose...

N-Acetylneuraminic acid aldolase, use in fluorinated sugar synthesis, 158,161/ Acylation-hydrolysis of ylides, 2-fluoro-2-oxoalkanoate synthesis, 96-100 Acyl hypofluorites applications, 58 applications for shorter chain homologues, 60,61/ chemistry, 58—61... 

SYNTHESIS OF FLUORINATED SUGARS FROM FLUORINE-CONTAINING SYNTHONS... 

Up to date, a lots of fluorinated compounds were synthesized and biologically evaluated. Among these fluorinated compounds, fluorinated sugars have recently attracted more and more attentions from organic and medicinal chemists. It should be noted that just one fluorine-containing carbohydrate derivative has been isolated from... 

These enzymes would be useful for the synthesis of fluorinated sugars if they would accept fluorinated molecules as substrates. We are in the process of exploring other types of aldolases as synthetic catalysts. 

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