Flueggea

Flueggea virosa Willd Voight Euphorbiaceae trop S. Afr, trap subtrop Asi, Ausr Mas roots epilepsy decoction 33... 

P. simplex (37) P. niruri (38, 47) Zygogynum pauciflorum (43) Flueggea leucopyra (26) Flueggea virosa (39, 36) Flueggea virosa (39)... 

Flueggea virosa (51) Flueggea virosa (51) Flueggea virosa (52) Flueggea virosa (52) Z3 0 CP... 

Compound 14 was isolated from the leaves and twigs of Flueggea leu-copyra ( = F. leucopyrus Willd.) as an yellow oil, and its molecular formula was determined as C14H19NO4 on the basis of HRESIMS analysis. Presence of the butenolide unit was evidenced by its IR spectrum... 

More recently, two additional neosecurinane alkaloids, virosine A (22) and B (23), were isolated from Flueggea virosa by Ye. The case of virosine A (22) is intriguing. Indeed, the proposed stmcture for virosine A (22) referred to securinol B but after careful analysis it is evident that the reported data for these compounds are different ( H NMR shifts and [a]o values). Moreover, these compounds were isolated from plants known for producing enantiomers, thus the probability to extract the same enantiomer from these sources is almost impossible. Besides, the proposed structure for virosine A (22) was supported by detailed 2D NMR and CD analysis, whereas the revised structure stipulated for securinol B was extrapolated from the revised structure of securinol A (21), which was secured by X-ray crystallography. In conclusion, from the actual data, one can propose that the structure of virosine A corresponds to that depicted above, in other terms virosine A (22) is the C8-epimer of securinol A (21). Concerning securinol B, additional studies are needed to establish its structure. 

Norsecurinine (27) was first isolated in 1963 from a Securinega virosa BaiU. (= Flueggea virosa (Roxb. ex WiUd.) Royle) species collected in... 

Epoxynorsecurinine (29) was isolated along with (—)-norsecu-rinine (27) from the barks of Flueggea virosa collected in South Africa. On the basis of the mass spectra (molecular peak at m/z 219), the formula... 

Compound 36 was isolated from Flueggea leucopyra Its analytical data were in agreement with the structure of a stereoisomer of compound 35. On the basis of the NOESY correlations, it was suggested that the both differed only by their configuration at Cl 5. This information was confirmed by comparison of the CD spectrum of 36 with those of 15P-hydroxy-14,15-dihydronorsecurinine (34), 15p-methoxy-14,15-... 

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