Pentostatin Fludarabine

FLUDARABINE PENTOSTATIN Risk of severe and potentially fatal pulmonary toxicity Uncertain Avoid co-administration... 

Clinically important, potentially hazardous interactions with fludarabine, pentostatin... 

Folic acid antagonists methotrexate, raltitrexed. Purine derivatives cladribine (2-chlorodeoxyadeno-sine), fludarabine, mercaptopurine, pentostatin (deoxycoformycin), tioguanine. 

Folate analogs Methotrexate Pemetrexed Trimetrexate Purine analogs Cladribine Fludarabine Mercaptopurine Pentostatin Thioguanine Pyrimidine analogs Capecitabine Cytarabine Floxuridine Fluorouracil Gemcitabine... 

Clinically important, potentially hazardous interactions with altretamine, amikacin, aminoglycosides, antineoplastics, bleomycin, busulfan, carboplatin, carmustine, chlorambucil, cisplatin, corticosteroids, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, docetaxel, doxorubicin, estramustine, etoposide, fludarabine, fluorouracil, gemcitabine, gentamicin, hydroxyurea, idarubicin, ifosfamide, indomethacin, kanamycin, levamisole, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitotane, mitoxantrone, neomycin, pentostatin, plicamycin, procarbazine, streptomycin, streptozocin, thioguanine, thiotepa, tobramycin, tretinoin, uracil, vinblastine, vincristine, vinorelbine... 

The pnrine nncleoside analogs fludarabine, 2-chlorodeoxy-adenosine (cladribine), and 2-deoxycoformycin (pentostatin), have... 

Analogs of naturally occurring purine bases with antileukemic, immunosuppressant, and antiviral properties include mercaptopurine, thioguanine, azathioprine, acyclovir, ganciclovir, vidara-bine, and zidovudine. Other purine analogs important in cancer therapy include pentostatin (2 -deoxycoformycin), cladribine, and fludarabine phosphate. 

Toxic manifestations include myelosuppression, GI symptoms, rashes, and abnormal liver function studies at standard (4 mg/rri ) doses. Depletion of normal T cells occurs at these doses, and neutropenic fever and opportunistic infections can occur. Immunosuppression may persist for several years after discontinuation of pentostatin therapy. At higher doses (10 mg/m ), major renal and neurological complications are encountered. The use of pentostatin in combination with fludarabine phosphate may result in severe or even fatal pulmonary toxicity. 

When fludarabine phosphate and pentostatin were used in the treatment of chronic lymphoid leukaemia, 4 out of 6 patients de-... 

Antimetabolites 5-fluorouracil (5-FU), 6-mercaptopurine (6-MP), Capecitabine, Floxuridine, Fludarabine, Gemcitabine, Hydroxyurea, Methotrexate, Pentostatin, Thioguanine ... 

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