Fludarabine

O Brien S, Moore JO, Boyd TE et al (2007) Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. J Clin Oncol 25(9) 1114-1120... [Pg.188]

CjjHjf.NsO 25146-54-7) see Fludarabine phosphate diacetone-2-oxo-L-gulonic acid (C 2H],07 18467-77-1) see Ascorbic acid diacetone-L-sorbose... [Pg.2343]

Fludarabine is an analog of the purine adenine. It interferes with DNA polymerase to cause chain termination and inhibits transcription by its incorporation into RNA. Fludarabine is dephosphorylated rapidly and converted to 2-fluoro-Ara-AMP (2-FLAA), which enters the cells and is phosphorylated to 2-fluoro-Ara-ATP, which is cytotoxic. Fludarabine is converted rapidly to 2-FLAA. The pharmacokinetics of 2-FLAA... [Pg.1285]

Fludarabine-based chemotherapy is used increasingly as first-line therapy for younger patients with chronic lymphocytic leukemia (CLL). [Pg.1415]

Chronic lymphocytic leukemia (CLL) patients who receive fludarabine-based combination chemotherapy and rituximab may have long-term disease-free survival. [Pg.1415]

The most commonly used dose for fludarabine is 20 mg/m2 intravenously daily for 5 consecutive days, whereas chlorambucil can be taken daily as an oral tablet with the dose ranging from 4 to 10 mg/day.21 Fludarabine is associated with more toxicities than chlorambucil, including myelosuppression and prolonged immunosuppression.19 Resulting infectious complications may occur during the periods of prolonged immunosuppression. The ease of administration and limited side effects make chlorambucil a practical option for symptomatic elderly patients who require palliative therapy... [Pg.1419]

Fludarabine (Fludara) Myelosuppression prolonged immunosuppression resulting in secondary infectious complications edema neurotoxicity Dose 20 mg/m2 IV daily for S days. [Pg.1420]

Combination therapy may provide improvement in longterm disease-free survival. The combination of fludarabine, cyclophosphamide, and rituximab improves CR rates compared with fludarabine alone (70% versus 20%) but at the expense of increased infections.28,29 Combinations of fludarabine and alemtuzumab are also being investigated, with the hope of improving overall survival.21... [Pg.1420]

AS is a 65-year-old woman with relapsed acute myelogenous leukemia. PMH is significant for type II diabetes and renal insufficiency (CrCI 20 mL/minute). She is day +1 from a nonmyeloablative HCT with fludarabine (30 mg/m2 per day IV for 3 days) and total-body irradiation preparative regimen and a graft from a full HLA-matched sibling. [Pg.1463]

CNT3 5-fluorouridine, floxuridine, zebularine, gemcitabine, AZT, dadribine, fludarabine, ddl... [Pg.253]

Equilibrative nudeoside ENT1 dadribine, cytarabine, fludarabine,... [Pg.253]

Fludarabine Consider prophylactic use of trimethoprin-sulfamethoxazole Fludarabine 25 mg/M2 IV days 1-5... [Pg.93]

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