Flavonoid interactions, consequences

Consequences of Flavonoid Interactions on Membrane-Associated Processes 122... 

Flavonoids bear different degrees of hydroxylation, polymerization, and methylation that define both specific and nonspecific interactions with membrane lipids. Molecule size, tridimensional structure, and hydrophili-city/hydrophobicity are chemical parameters that determine the nature and extent of flavonoid interactions with lipid bilayers. The hydrophilic character of certain flavonoids and their oligomers endows these molecules with the ability to bind to the polar headgroups of lipids localized at the water-lipid interface of membranes. On the other hand, flavonoids with hydrophobic character can reach and cross the lipid bilayer. In this section, we will discuss current experimental evidences on the consequences of flavonoid interactions with both the surface and the hydrophobic core of the lipid bilayer. 

CONSEQUENCES OF FLAVONOID INTERACTIONS ON MEMBRANE-ASSOCIATED PROCESSES... 

As a consequence of flavonoid-lipid interactions, flavonoids affect several physical properties of the bilayer. Studies from our laboratory demonstrated... 

To fully understand the actual mechanism of action of dietary flavonoids either as antioxidants, modulators of cell signalling, or inflammatory pathways, it is important to detect and identify their metabolites in vivo as well as to study the consequences of interaction of these circulating metabolites with cells. Animal models and human studies should also be conducted to identify the in vivo mechanism of action of dietary flavonoids. Results of such studies are crucial in the evaluation of their potential as cardiovascular protective agents and may eventually lead to specific advice regarding intake of foods and beverages rich in flavonoids and attempts to alter and enhance flavonoid content of a range of foods. 

The mode of action of phytochemicals in the prevention of CVD is multifaceted and is dependent on the chemical natures of the individual phytochemicals in question and on the consequences of their complex interactions. The most extensively studied group is undoubtedly the flavonoids. 

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