Flavones diosmetin

Mono-C-glucosyl flavones Diosmetin (7 or 8) having the glucosyl group at C-6 or C-8... 

F.I. Kanaze, M.I. Bounartzi and I. Niopas, A validated HPLC determination of the flavone aglycone diosmetin in human plasma. Biomed. Chromatogr. 18 (2004) 800-804. 

Different extracts of Citrus were subjected to SPE on Cig cartridges to remove polar components. The retained flavonoids (mainly flavanones) were eluted with methanol-dimethyl sulfoxide, which enhanced solubility of hesperidin, diosmin, and diosmetin. Recoveries of eriocitrin, naringin, hesperidin, and tangeretin from spiked samples of mesocarp tissue exceeded 96%. Flavones were relatively abundant in the leaves. ... 

Series of cassiaoccidentalins built on a 6-C-(6-deoxy-ribo-hexos-3-ulosyl)flavone general structure, and isolated from Cassia — cassiaoccidentalin A 6-C-glycosyl 2 -0-rhamnosyl)apigenin B 6-C-glycosyl (2"-0-rhamnosyl)luteolin and C 6-C-glycosyl (2"-0-rhamnosyl)diosmetin. 

About 300 different aglycones have been identified, and the most frequently are luteolin, apigenin (especially in parsley) and diosmetin (in Citrus fruits). Among glycosides, the 1-0- and C-forms are very common, and are characterized by a carbon-carbon bond between the anomeric carbon of a sugar molecule and the Q or Cg carbon of the flavone nucleus. Table 8 describes the most common flavones [19]. 

Substantial quantities of luteolin-7-O-glucuronide, luteolin-7-O-glucoside, and luteolin-7-O-rutinoside occur in Red Oak Leaf and Lollo Rosso, two red-leaved varieties of lettuce (Lactuca sativa) [Llorach et al., 2008], Polymethoxylated flavones such as nobiletin, scutellarein, sinensetin, and tangeretin (Fig. 1.8) are found exclusively in citrus species [Crozier et al., 2006c], while diosmetin-7-O-glucuronide has been isolated from the fruits of a Chinese herb, Luffa cylindrical. 

Diosmetin (= 5,7, 3 -Trihydroxy-4 -methoxyflavone) (flavone) Arnica spp. (Asteraceae), Salvia tomentosa (Lamiaceae), Stemodia viscosa (Scrophulariaceae) Aminopeptidase N (45% inhibition at 300 pM) [63]... 

In our first study with Salvia species, S. triloba L.f. [8] we have isolated a new flavone salvigenin (1) (6,7,4 -trimethylapigenin), later the same compound was obtained from other Salvia species. From S. tomentosa [9] cirsimaritin (2), jaceosidin (3), 5-hydroxy-6,7,3 ,4 -tetramethoxyflavone (4), 6-methoxyluteolin (5), luteolin (6), luteolin 7-glucoside (7) were isolated, in an other study with the same plant [10] further compounds eupatilin (8), cirsilineol (9), diosmetin (10), 6-hydroxyluteolin 7- and 5-glucosides (11 and 12) were obtained. 

S. blepharophylla Brandegee ex. Epling [18] has yielded eight flavone and flavone glycosides such as pedalitin (34), diosmetin (10), quercetin 3-0-glucoside (24), vitexin (35), schaftosid (36), and miquelianin (37) (quercetin 3-0-/ -D-glucuronopyranoside). 

Flavones Apigenin, luteolin, diosmin and diosmetin. Found mainly in herbs, parsley, celery, citrus fruits, olives, peppers, red grapes, and some beans. Antiproliferative effect [67,70-73], Antimitotic [79], Inactivation of carcinogenesis mediated by chemicals [90, 91, 92], Inhibition of angiogenesis [108, Cardiovascular properties [99,100, 114], 10-4,000... 

Flavones (e.g., apigenin, luteolin, diosmetin), flavonols (e.g., quercetin, myricetin, kaempferol), and their glycosides are the most common compounds among the flavonoids. They exist widely in the plant kingdom, with the exception of algae and fungi. 

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