Ventricular tachycardia fish oils

Raitt, M. H., Connor, W. E., Morris, C., Kron, J., Halperin, B., Chugh, S. S., McClelland, J., Cook, J., and MacMurdy, K. (2005). Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators A randomized controlled trial. JAMA 293, 2884-2891. 

Some of the beneficial effects of fish oils after acute myocardial infarction have been attributed to an antidysr-hythmic effect on the heart (5). However, the results of a randomized trial in 200 patients with implantable cardioverter defibrillators are at variance with this the rate of cardioversion was higher in those taking fish oils 1.8 g/day than in a control group who took olive oil (6). The lack of benefit and the suggestion that fish oil supplementation may increase the risk of ventricular tachycardia or ventricular fibrillation in some patients with implantable cardioverter defibrillators can reasonably be interpreted as evidence that the routine use of fish oil supplementation in patients with implantable cardioverter defibrillators and recurrent ventricular dysrhythmias should be avoided. 

Cardiovascular In a systematic review of deaths in 12 randomized controlled trials of fish oil as dietary supplements in 32 779 patients there was no beneficial effect in three studies ( = 1148) of implantable cardiac defibrillators (OR = 0.90 95% Cl = 0.55, 1.46) or in six studies (n = 31 111) of sudden cardiac death (OR = 0.81 0.52,1.25). In 11 studies (n = 32 439 and n = 32 519) there was a reduction in deaths from cardiac causes (OR = 0.80 0.69,0.92) but no effect on dysrhythmias or all-cause mortahty [21 ]. However, it was later pointed out that there is some evidence that fish oils may be dysrhyth-mogenic in some subgroups of patients with heart disease 22f. These include an increased risk of ventricular tachycardia in patients with implantable cardiovertor defibrillators whose primary dysrhythmia was ventricular tachycardia [23 ], and an increased risk of cardiac death in patients with angina [24 ]. 

Shnider R, McAnulty J. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators a randomized controlled trial. JAMA 2005 293(23) 2884-91. 

---

See also in sourсe #XX -- [ ]

---