Films sodium hyaluronate

Fig. 14.—Circular Dichroism of an i-Carrageenan Film and a Sodium Hyaluronate Film (—). (Redrawn from Refs. 27 and 29.)...

Hamano, T., et al. 1996. Sodium hyaluronate eye drops enhance tear film stability. Jpn J Ophthalmol 40 62. 

Positive effects on the tear film and ocular surface have not been reported by all researchers, however.Two studies showed no significant advantage of sodium hyaluronate over chondroitin sulfate or PVA, respectively. In a clinical study involving 104 dry eye patients, no statistical... 

Hyaluronic acid is used topically to promote wound healing. A film containing hyaluronate sodium and carmel-lose is used to prevent surgical adhesion. Hyaluronic acid is increasingly being used in cosmetic dermatology to treat wrinkles in patients who are sensitive to bovine collagen. 

Hyaluronate. Synthetic polymers and polysaccharides have been subjected to dichroism studies for structural information (Liang and Marchessault, 1959b Pearson et al, 1960). Quinn and Bettelheim (1963) used such methods on sodium hyaluronate isolated from umbilical cords. Figures 6.7a and 6.7b show the spectrum of an oriented sodium hyaluronate film which has been elongated by 40%. Table 6.6 contains band assignments made by these workers based on data reported in the literature. 

Fig. 6.7a. Infrared absorption spectra of sodium hyaluronate films,...

Fig. 6.7b. Infrared absorption spectra of sodium hyaluronate films, 40% elongation, from 4(X)0 to 2800 cmElectrical vector of polarized infrared...

Patients suffering from dry eye s3mdrome complain about tear film instability. Stability can be improved by increasing the viscosity of the tear film (see also Sect. 10.4.4) [34]. Viscoelastic polymers increase viscosity but also possess elastic properties. During blinking sodium hyaluronate (Na-HA) exhibits a kind of cushioning action and induces improved protection of the ocular surface compared to classical pseudoplastic viscosity enhancing polymers. 

Figure 1.12 Cross-sectional scanning electron microscopy images of EPD-fabricated composites or multilayered coatings (a) Laminate coatings of chitosan (Ch) and HA (H) with different layers on a graphite substrate (S) (b) 10 alternating layers of AI2O3 and Zr02 (c) polyacrylic acid films containing halloysite nanotubes (white arrows) on the platinized sihcon wafer substrate (d) sodium hyaluronate and bovine serum albumin composite films (H + B) on a graphite substrate (S).

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