Fibrous collagen, types

Collagen, a class of fibrous protein, is the most abundant protein in the human body, accounting for approximately 25% of the total protein mass. It is the main component of the ECM and serves as a stmctural protein in connective tissues, such as skin, bone, cartilage, and blood vessels. Twenty-eight types of collagen have been identified in humans to date (Kar et al. 2006). Among these, collagen types I-III are the most abundant. 

Types I, II, and III collagen form the fibrous network that prevents premature mechanical failure of most tissues and acts to transmit stress to and from cells. The molecular sequences of these collagens are known and they are composed of approximately 1000 amino acids in the form of Gly-X-Y with small nonhelical ends before and after these sequences. All of these collagen types form continuous triple-helical structures that pack laterally... 

Collagen is the major insoluble fibrous protein in the extracellular matrix and in connective tissue 80-90% of the collagen in the body consists of types 1, It and 111 (Table 12.2). The collagen superfamily consists of at least 20 collagen types, with as many as 38 distinct polypeptide chains and more than 15 additional proteins that have collagen-like domains. 

Collagen type IV/Dako/1 8 Fibrosis abscess sarcoma teratoma fibrous cyst and vessel walls dura Ventana protease 1,16 min... 

The elastic fibrous component of connective tissue, elastin, has often been examined by use of wide-angle diffraction techniques, applied to ligaments as sources of high elastin content. Earliest studies showed collagen-type diffraction (104), and Kolpak (126) found that stretching... 

Fibrous Aligned type i collagen fibers Compressive, tensile hoop, and shear stresses -i -fli... 

Tendons and ligaments are both fibrous tissues comprised of fibroblasts arranged in parallel that secrete a collagen type 1 and proteoglycan-rich matrix. Tendons connect muscles to bones, ligaments linkbones... 

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