Fibroblast growth factor-2 delivery system

Wu, D., et al. 2002. Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system. J Drug Target 10 239. 

Kuraitis et al. (2012) incorporated Fibroblast growth factor-2 into an alginate-based hydrogel and further encased this hydrogel into a CL capsule (CL cross-linked with GP) for implantation. As a result, tertiary encapsulation of growth factor-2 retards its release and allows for a more controlled and constant delivery of growth factor-2, while maintaining its bioactive effects on endothelial cells and systemic responses in vivo. 

Kang, CE, Tator, CH, and Shoichet, MS. 2010. Poly(ethylene glycol) modification enhances penetration of fibroblast growth factor 2 to injured spinal cord tissue from an intrathecal delivery system. / Control Release 144(1) 25-31. 

Other applications of pH-responsive polymers for drug-delivery systems have also been explored such as the incorporation of fibroblast growth factors to improve angiogenesis in infracted myocardium (Garbem et al., 2011) the incorporation of ketoprofen for colon-targeted delivery (Kulkami et al., 2012) intracellular delivery of ovalbumin to dendritic cells (a class of cells intimately involved with adaptive immunity) (Hn et al., 2007) and for controlling drug release in nocturnal asthma treatment (Tran et al., 2013). 

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